N-{4-[2,5-bis(4-bromobenzoyl)-3-thienyl]phenyl}acetamide | 1439388-08-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-{4-[2,5-bis(4-bromobenzoyl)-3-thienyl]phenyl}acetamide
• 英文别名: N-[4-[2,5-bis(4-bromobenzoyl)thiophen-3-yl]phenyl]acetamide
• CAS: 1439388-08-5
• 化学式: C₂₆H₁₇Br₂NO₃S
• 分子量: 583.3
• InChiKey: ZRRHVXAZONHDHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  91.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,4'-二溴苯乙酮 在 sodium sulfide 、 十六烷基三甲基溴化铵 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 sodium iodide 作用下， 以 乙醇 、 水 为溶剂， 反应 1.17h， 生成 N-{4-[2,5-bis(4-bromobenzoyl)-3-thienyl]phenyl}acetamide
  参考文献：
  名称：

  An Aquatic Pseudo-Four-Component Reaction for the Synthesis of Highly Substituted Thiophenes

  摘要：

  A novel and simple procedure was developed for the construction of fully substituted thiophenes. A series of alpha-haloacetophenone derivatives were converted into fully substituted thiophenes by treatment with sodium sulfide in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene and sodium iodide in aqueous ethanol under aerobic conditions. A mechanism for the reaction is proposed.

  DOI：

  10.1055/s-0032-1316866

文献信息

• An Aquatic Pseudo-Four-Component Reaction for the Synthesis of Highly Substituted Thiophenes
  作者：Hassan Zali-Boeini、Maryam Ghani

  DOI：10.1055/s-0032-1316866

  日期：——

  A novel and simple procedure was developed for the construction of fully substituted thiophenes. A series of alpha-haloacetophenone derivatives were converted into fully substituted thiophenes by treatment with sodium sulfide in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene and sodium iodide in aqueous ethanol under aerobic conditions. A mechanism for the reaction is proposed.