乐伐替尼杂质LFS-C | 2143930-76-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 乐伐替尼杂质LFS-C
• 英文名称: Dimethylamine Lenvatinib
• 英文别名: 4-[3-chloro-4-(dimethylcarbamoylamino)phenoxy]-7-methoxyquinoline-6-carboxamide
• CAS: 2143930-76-9
• 化学式: C₂₀H₁₉ClN₄O₄
• 分子量: 414.8
• InChiKey: WEXATQSILUOWFN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  107
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Polymorphs of 4-[3-chloro-4-(n′-cyclopropyl ureido)phenoxy] -7-methoxyquinoline-6-carboxamide, its salts and process for the preparation thereof
  申请人：MSN LABORATORIES PRIVATE LIMITED, R&D CENTER

  公开号：US11236050B2

  公开（公告）日：2022-02-01

  The present invention relates to novel polymorphs of 4-[3-chloro-4-(N′-cyclopropyl ureido) phenoxy]-7-methoxyquinoline-6-carboxamide methanesulfonate represented by following structural formula-1a and process for preparation thereof. Further, the present invention relates to an improved process for the preparation of 4-[3-chloro-4-(N′-cyclopropylureido) phenoxy]-7-methoxyquinoline-6-carboxamide compound of formula-1 or its salts and its intermediates thereof.

  本发明涉及结构式-1a 所代表的 4-[3-氯-4-(N′-环丙基脲基)苯氧基]-7-甲氧基喹啉-6-甲酰胺甲磺酸盐的新型多晶型物及其制备工艺。 此外，本发明还涉及一种制备式-1的4-[3-氯-4-(N′-环丙基脲基)苯氧基]-7-甲氧基喹啉-6-甲酰胺化合物或其盐类及其中间体的改进工艺。
• NOVEL POLYMORPHS OF 4-[3-CHLORO-4-(N'-CYCLOPROPYL UREIDO)PHENOXY]-7-METHOXYQUINOLINE-6-CARBOXAMIDE, ITS SALTS AND PROCESS FOR THE PREPARATION THEREOF
  申请人：SRINIVASAN Thirumalai Rajan

  公开号：US20210188778A1

  公开（公告）日：2021-06-24

  The present invention relates to novel polymorphs of 4-[3-chloro-4-(N′-cyclopropyl ureido) phenoxy]-7-methoxyquinoline-6-carboxamide methanesulfonate represented by following structural formula-1a and process for preparation thereof. Further, the present invention relates to an improved process for the preparation of 4-[3-chloro-4-(N′-cyclopropylureido) phenoxy]-7-methoxyquinoline-6-carboxamide compound of formula-1 or its salts and its intermediates thereof.