2-(2',4'-dimethoxybiphenyl-4-yl)-6-fluoro-3-methylquinoline-4-carboxylic acid | 641611-82-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(2',4'-dimethoxybiphenyl-4-yl)-6-fluoro-3-methylquinoline-4-carboxylic acid
• 英文别名: 2-[4-(2,4-Dimethoxyphenyl)phenyl]-6-fluoro-3-methylquinoline-4-carboxylic acid
• CAS: 641611-82-7
• 化学式: C₂₅H₂₀FNO₄
• 分子量: 417.437
• InChiKey: QFAATEHRMDUPBO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  68.6
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• PHOSPHODIESTERASE INHIBITOR
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP1541149A1

  公开（公告）日：2005-06-15

  [wherein n represents an integer of from 1 to 4, R1 represents substituted or unsubstituted lower alkyl, -C(=Y)R9 or the like, R2 represents a hydrogen atom, substituted or unsubstituted lower alkyl or the like, R3 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, a substituted or unsubstituted heterocyclic group or the like, and R4 represents halogen or the like.] A phosphodiesterase 10A inhibitor which comprises a quinoline derivative represented by the above formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient is provided.

  提供一种磷酸二酯酶10A抑制剂，其包括上述式（I）所代表的喹啉衍生物或其药用盐作为活性成分。其中n表示1到4之间的整数，R1代表取代或未取代的较低烷基，-C(=Y)R9或类似物，R2代表氢原子，取代或未取代的较低烷基或类似物，R3代表取代或未取代的较低烷基，取代或未取代的芳基，取代或未取代的杂环基团或类似物，R4代表卤素或类似物。
• Phosphodiesterase inhibitor
  申请人：Osakada Naoto

  公开号：US20060111368A1

  公开（公告）日：2006-05-25

  [wherein n represents an integer of from 1 to 4, R 1 represents substituted or unsubstituted lower alkyl, —C(═Y)R 9 or the like, R 2 represents a hydrogen atom, substituted or unsubstituted lower alkyl or the like, R 3 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, a substituted or unsubstituted heterocyclic group or the like, and R 4 represents halogen or the like.]A phosphodiesterase 10A inhibitor which comprises a quinoline derivative represented by the above formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient is provided.

  提供一种磷酸二酯酶10A抑制剂，其包括上述式（I）所代表的喹啉衍生物或其药学上可接受的盐作为活性成分，其中n表示1至4的整数，R1表示取代或未取代的低碳基，-C（═Y）R9或类似物，R2表示氢原子，取代或未取代的低碳基或类似物，R3表示取代或未取代的低碳基，取代或未取代的芳基，取代或未取代的杂环基或类似物，R4表示卤素或类似物。