4-(N,N-二乙基氨基)苯甲酸乙酯 | 10287-54-4

• 物质功能分类: 化学试剂 - 有机试剂 - 酯类
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-(N,N-二乙基氨基)苯甲酸乙酯
• 英文名称: p-N,N-diethylaminobenzoic acid ethyl ester
• 英文别名: ethyl 4-(N,N-diethylamino)benzoate；ethyl p-(N,N-diethylamino)benzoate；ethyl 4-N,N-diethylaminobenzoate；ethyl 4-(diethylamino)benzoate；Ethyl p-diethylaminobenzoate；ethyl 4-diethylaminobenzoate
• CAS: 10287-54-4
• 化学式: C₁₃H₁₉NO₂
• 分子量: 221.299
• InChiKey: XPKFLEVLLPKCIW-UHFFFAOYSA-N

物化性质

• 熔点：
  39-43°C
• 沸点：
  362.36°C (rough estimate)
• 密度：
  1.0451 (rough estimate)
• 保留指数：
  1873

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2922499990
• WGK Germany：
  3
• 储存条件：
  应存放在室温、干燥、密封的环境中。

反应信息

• 作为反应物：
  描述：

  4-(N,N-二乙基氨基)苯甲酸乙酯 在 硝酸 、 溶剂黄146 作用下， 生成 4-(ethyl-nitroso-amino)-3,5-dinitro-benzoic acid ethyl ester
  参考文献：
  名称：

  Reverdin; de Luc, Chemische Berichte, 1909, vol. 42, p. 1727

  摘要：

  DOI：
• 作为产物：
  描述：

  碘乙烷 、 苯佐卡因 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 以70%的产率得到4-(N,N-二乙基氨基)苯甲酸乙酯
  参考文献：
  名称：

  Design of Branched and Chiral Solvatochromic Probes:  Toward Quantifying Polarity Gradients in Dendritic Macromolecules

  摘要：

  [GRAPHICS]A pair of chiral, branched monomer building blocks, consisting of a solvatochromic probe and a spectroscopically inactive volume dummy, has been developed. The probe can selectively be excited, and its fluorescence characteristics provide information about local polarity. Incorporation of these monomers into high-generation polyester clendrimers should enable a detailed investigation of the polarity/density profile in dendritic architectures and ultimately allow for the realization of energy gradients from one chromophore building block only.

  DOI：

  10.1021/ol0519902

文献信息

• A strategy of two-step tandem catalysis towards direct N-alkylation of nitroarenes with ethanol via facile fabricated novel Co-based catalysts derived from coordination polymers
  作者：Jing Wang、Tianqinji Qi、Zhibin Li、Wei She、Xuewei Li、Jingfang Li、Pengfei Yan、Weizuo Li、Guangming Li

  DOI：10.1016/j.jcat.2019.07.002

  日期：2019.8

  the first carbon-nitrogen species supported Co/Co3O4 catalysts derived from the CPs, which could effectively catalyzed the N-alkylation of nitroarenes with ethanol to produce the secondary amines and/or tertiary amines. This low-cost, recyclable and easy scale-up N-doped carbon supported catalyst may be of potential application in various heterogeneous catalytic reactions.

  三种新型掺杂的N -碳负载CO / CO2 3 ö 4催化剂，即，[电子邮件保护] HMTA，[电子邮件保护] LARG和Co的Co 3 ö 4 @ CN-联吡啶，以片状，支持WORM，蜂巢状形态分别通过定义明确的配位聚合物（CP）的热解制备。将所制备的催化剂用于硝基芳烃与乙醇的N-烷基化反应后，可实现直接的两步串联反应，其中[受电子邮件保护的] hmta可实现100％的N-乙基苯胺/ N转化率/选择性，来自硝基芳烃与乙醇的直接N-烷基化反应的N-二乙基苯胺。进行动力学研究以证实苯胺与乙醇的N-烷基化是两步串联反应中的速率决定步骤。SEM / EDX，XRD，Raman，TEM，XPS和CO 2 -TPD表征结果表明，可以通过改变Co的结构来调节金属Co的尺寸和分散度，结构缺陷的数量以及对三种催化剂的表面路易斯碱度。不同有机连接基设计的基于CP的CP，这也可能有助于从分子水平理解工业催化剂的制备。优化的[受电子邮件保护]
• Phosphonomethylation of anesthesin and radioprotectant activity of the products
  作者：V. K. Khairullin、M. A. Vasyanina、R. Z. Musin、A. N. Pudovik、G. G. Batulina

  DOI：10.1007/bf00758444

  日期：1988.2

  order to obtain esters of (p-ethoxycarbonylphenylaminomethyl)phosphonic acid. Three compounds were synthesized and their toxic and radioprotectant properties examined. As is well known, the phosphonomethylation of amines can be effected by reacting them with paraformaldehyde and trialkyl phosphites [2, 3, 6], or by the Kabachnik--Fields reaction with paraformaldehyde and dialkyl phosphites [5, 12]. It

  我们现在第一次使用膦酰基甲基化麻醉剂以获得（对乙氧基羰基苯基氨基甲基）膦酸的酯。合成了三种化合物并检查了它们的毒性和辐射防护特性。众所周知，胺的膦酰基甲基化可以通过将它们与多聚甲醛和亚磷酸三烷基酯反应 [2, 3, 6]，或通过与多聚甲醛和亚磷酸二烷基酯的 Kabachnik--Fields 反应来实现 [5, 12]。还已知第一个系统优选用于对氨基苯酚和对苯胺 [4] 的膦酰甲基化。
• Iodine‐Catalyzed Oxidative Rearrangement of Amines to α‐Amino Acetals and α‐Amino Aldehydes
  作者：Min‐Jie Zhou、Shou‐Fei Zhu、Qi‐Lin Zhou

  DOI：10.1002/adsc.201801670

  日期：2019.3.15

  A protocol for iodine‐catalyzed oxidative rearrangement of tertiary and secondary amines has been developed. This metal‐free protocol provides an atom‐economical, efficient access to synthetically useful α‐amino acid derivatives from readily available acyclic and cyclic tertiary or secondary amines.

  已开发出碘催化的叔胺和仲胺氧化重排的方案。该无金属方案可从经济易得的无环和环状叔或仲胺原子经济有效地获得合成有用的α-氨基酸衍生物。
• Novel, solid-state, highly fluorescent β-ketoiminate spiroborates with aggregation induced emission
  作者：Haribhau S. Kumbhar、Saurabh S. Deshpande、Ganapati S. Shankarling

  DOI：10.1016/j.dyepig.2016.01.006

  日期：2016.4

  synthesized spiroborates were investigated. These spiroborates showed intense fluorescence in the solid-state and weak fluorescence in solution. These spiroborates showed prominent aggregation induced emission activity because of restricted intramolecular rotations of the aryl rings. The salicyl spiroborates showed better fluorescence property than the corresponding catechol spiroborates. The structural

  合成了新型的含有β-酮亚胺基配体的邻苯二酚和水杨基螺硼酸酯，它们显示出酮-烯醇互变异构现象。研究了合成的螺硼酸酯的荧光性质。这些螺硼酸酯在固态中显示出强荧光，而在溶液中显示出弱荧光。由于芳基环的分子内旋转受限制，这些螺硼酸酯显示出显着的聚集诱导的发射活性。水杨基螺硼酸酯显示出比相应的邻苯二酚螺硼酸酯更好的荧光性质。通过使用密度泛函理论（DFT）评估结构，电子和光谱性质。
• NEGATIVE PHOTOSENSITIVE RESIN COMPOSITION, CURED FILM, ELEMENT PROVIDED WITH CURED FILM, DISPLAY DEVICE PROVIDED WITH ELEMENT, AND ORGANIC EL DISPLAY
  申请人：TORAY INDUSTRIES, INC.

  公开号：US20190302617A1

  公开（公告）日：2019-10-03

  The present invention provides a negative photosensitive resin composition that has high pigment dispersibility and stability and can reduce residues of unexposed portions during development. The present invention provides a negative photosensitive resin composition containing an (A) alkali-soluble resin, a (B) dispersant having an amine value exceeding 0, a (C) benzofuranone based organic pigment having an amide structure, a (D) radical polymerizable compound, and a (E) photoinitiator. In this negative photosensitive resin composition, the (A) alkali-soluble resin contains one or more selected from the group consisting of a (A1) polyimide, a (A2) polyimide precursor, a (A3) polybenzoxazole, and a (A4) polybenzoxazole precursor, and the (B) dispersant having an amine value exceeding 0 contains a (B1) dispersant including a repeating unit represented by general formula (2) and a repeating unit represented by general formula (3) and a (B2) dispersant that is an acrylic block copolymer having an amine value of 15 to 60 mgKOH/g and/or a (B3) dispersant having a urethane bond. (In general formula (2), R 1 represents an alkylene group. R 2 and R 3 , which may be the same or different, each represents hydrogen, an alkyl group or a hydroxyl group. x represents an integer of 0 to 20. However, when x is 0, at least one of R 2 and R 3 is an alkyl group. m represents an integer of 1 to 100. In general formula (3), n represents an integer of 1 to 100.)

  本发明提供了一种具有高颜料分散性和稳定性的负性感光树脂组合物，可以减少在显影过程中未曝光部分的残留物。本发明提供了一种包含（A）可溶于碱性树脂、（B）胺值超过0的分散剂、（C）苯并呋喃酮基有机颜料（具有酰胺结构）、（D）自由基聚合化合物和（E）光引发剂的负性感光树脂组合物。在这种负性感光树脂组合物中，（A）可溶于碱性树脂包含从以下组中选择的一种或多种：（A1）聚酰亚胺、（A2）聚酰亚胺前体、（A3）聚苯并噁唑和（A4）聚苯并噁唑前体；而具有胺值超过0的（B）分散剂包括具有由通用公式（2）表示的重复单元和由通用公式（3）表示的重复单元的（B1）分散剂，以及胺值为15至60 mgKOH/g的丙烯酸酯嵌段共聚物（B2）和/或具有脲键的（B3）分散剂。（在通用公式（2）中，R1表示烷基基团。R2和R3，可能相同也可能不同，每个表示氢、烷基基团或羟基。x表示0到20的整数。但是，当x为0时，R2和R3中至少有一个是烷基基团。m表示1到100的整数。在通用公式（3）中，n表示1到100的整数。）