1-α-D-glucopyranosyl-D-fructopyranose | 90689-37-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-α-D-glucopyranosyl-D-fructopyranose
• 英文别名: trehalulose；Glc(a1-1)Fru；(3S,4R,5R)-2-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxane-2,3,4,5-tetrol
• CAS: 90689-37-5；130744-90-0
• 化学式: C₁₂H₂₂O₁₁
• 分子量: 342.3
• InChiKey: SVBWNHOBPFJIRU-TZLCEDOOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  190
• 氢给体数：
  8
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  1-α-D-glucopyranosyl-D-fructopyranose 在 氨 sodium tungstate 、 磷酸 、 双氧水 作用下， 以 水 为溶剂， 以59%的产率得到carboxymethyl α-D-glucopyranoside
  参考文献：
  名称：

  将葡糖基部分锚定在亲核物质上的简单方法：胺和醇与羧甲基3,4,6-三-O-乙酰基-α-D-吡喃葡萄糖苷2-O-内酯的反应。

  摘要：

  在碱性催化下，羧甲基3,4,6-三-O-乙酰基-α-D-吡喃葡萄糖苷2-O-内酯（由异麦芽酮糖制备）与氨基酸和脂肪胺的碱催化反应产生了一系列新的假葡萄糖肽，非离子两亲物和可聚合衍生物。应用于醇的相同反应提供了带有碱性或酸性催化剂的相应的2-（α-D-吡喃葡萄糖基氧基）乙酰基酯。

  DOI：

  10.1021/jo0300237

文献信息

• Derivatives of polyene macrolides and preparation and use thereof
  申请人：Micrologix Biotech Inc.

  公开号：US20040029817A1

  公开（公告）日：2004-02-12

  The present invention provides a new class of polyene macrolide derivatives useful for treating or preventing fungal infections. The new polyene macrolide derivatives exhibit surprisingly superior antifungal activity and water solubility compared to amphotericin B methyl ester (AME). In addition, the new polyene macrolide derivatives have improved water solubility and lower toxicity than both amphotericin B (AmB) and AME.

  本发明提供了一类新的多烯大环内酯衍生物，可用于治疗或预防真菌感染。与两性霉素 B 甲酯（AME）相比，新的多烯大环内酯衍生物表现出惊人的抗真菌活性和水溶性。此外，与两性霉素 B（AmB）和 AME 相比，新型多烯大环内酯衍生物的水溶性更好，毒性更低。
• Hydrogen peroxide oxidation of palatinose and trehalulose: direct preparation of carboxymethyl α-d-glucopyranoside
  作者：Stéphane Trombotto、Alain Bouchu、Gérard Descotes、Yves Queneau

  DOI：10.1016/s0040-4039(00)01440-4

  日期：2000.10

  The direct oxidation of palatinose and trehalulose by hydrogen peroxide in acidic medium provided carboxymethyl alpha -D-glucopyranoside (alpha -CMG) in moderate to fair yields in a single step. The effect of catalytic sodium tungstate on the reaction was studied. alpha -CMG is a versatile synthon able to supply a glucosyl moiety through the acylation of alcohols or amines, via the opening of the delta -lactone obtained by acetylation. (C) 2000 Elsevier Science Ltd. All rights reserved.
• Sulfur Atom Participation in Thiooligosaccharide Chemistry:  Synthesis of 1‘-Thiotrehalulose and 1‘-<i>epi</i>-Thiotrehalulose and Comparative Reactivity with the O-Linked Disaccharide Analogue, Trehalulose
  作者：José M. García Fernández、Carmen Ortiz Mellet、Jacques Defaye

  DOI：10.1021/jo972203k

  日期：1998.5.1
• [EN] LIQUID HIGH-FAT PROTEIN COMPOSITION<br/>[FR] COMPOSITION LIQUIDE DE PROTÉINES À HAUTE TENEUR EN MATIÈRES GRASSES
  申请人：NUTRICIA NV

  公开号：WO2010047581A1

  公开（公告）日：2010-04-29

  The invention concerns nutritional compositions for persons with a (partially) functional gastrointestinal tract, who are unwilling and/or unable to consume sufficient quantities of conventional food to meet their nutritional requirements such as malnourished persons or persons at risk of becoming malnourished, andin need of liquid oral nutrition. The shelf-stable liquid nutritional compositions comprise at least non-micellar casein, a heat stabilisation system and a high amount of fat.
• [EN] LIQUID ENTERAL NUTRITIONAL COMPOSITION WITH A LOW MONOVALENT METAL ION CONTENT<br/>[FR] COMPOSITION NUTRITIONNELLE ENTÉRALE LIQUIDE AVEC UNE FAIBLE TENEUR EN ION MÉTALLIQUE MONOVALENT
  申请人：NUTRICIA NV

  公开号：WO2010140877A1

  公开（公告）日：2010-12-09

  Liquid enteral nutritional composition with a low monovalent metal ion content are provided that contain micellar casein and optionally caseinate, and in which the total amount of monovalent metal ions is less than 25 mg/g of protein. Also, liquid enteral nutritional compositions are disclosed comprising 10 to 20 g of protein per 100 ml of the composition, in which all or a major part of said protein comprises micellar casein. Also, a method is disclosed for producing the composition according to the invention, comprising a step wherein an aqueous protein solution in which all or a major part of said protein comprises micellar casein, is subjected to an evaporation step.