10-Methyl-1-(2-pyrrolidin-1-yl-ethoxy)-10H-acridin-9-one | 66981-97-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 10-Methyl-1-(2-pyrrolidin-1-yl-ethoxy)-10H-acridin-9-one
• 英文别名: 10-Methyl-1-(2-pyrrolidin-1-ylethoxy)acridin-9-one
• CAS: 66981-97-3
• 化学式: C₂₀H₂₂N₂O₂
• 分子量: 322.407
• InChiKey: RFDPFNJEYVXJPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  32.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE
  申请人：ABBOTT LABORATORIES

  公开号：EP1711463A2

  公开（公告）日：2006-10-18
• US4150134A
  申请人：——

  公开号：US4150134A

  公开（公告）日：1979-04-17
• US4244954A
  申请人：——

  公开号：US4244954A

  公开（公告）日：1981-01-13
• [EN] AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE<br/>[FR] DERIVES TRICYCLIQUES A SUBSTITUTION AMINO ET LEURS PROCEDES D'UTILISATION
  申请人：ABBOTT LAB

  公开号：WO2005077899A2

  公开（公告）日：2005-08-25

  Compounds of formula (I) wherein A and B are amine-substituted sidechains, Y1 and Y2 form various tricyclic cores, Xa and Xb are C, CH, or N, as defined herein, and Rx is an optional substituent. Compounds and compositions of formula (I) are contemplated as well as methods for treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands that encompass compounds of formula (I) and other tricyclic derivatives. Methods of using amino-substituted tricyclic derivatives also are described herein.