2,2-dimethylpropionic acid (4aR,10aR)-7-(2,2-dimethylpropionyloxy)-1-n-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl ester trifluoroacetate | 1123299-89-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2,2-dimethylpropionic acid (4aR,10aR)-7-(2,2-dimethylpropionyloxy)-1-n-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl ester trifluoroacetate
• 英文别名: [(4aR,10aR)-7-(2,2-dimethyl-propionyloxy)-1-n-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinolin-6-yl] 2,2-dimethyl-propionate trifluoroacetate；[(4aR,10aR)-6-(2,2-dimethylpropanoyloxy)-1-propyl-3,4,4a,5,10,10a-hexahydro-2H-benzo[g]quinolin-7-yl] 2,2-dimethylpropanoate;2,2,2-trifluoroacetic acid
• CAS: 1123299-89-7
• 化学式: C₂HF₃O₂*C₂₆H₃₉NO₄
• 分子量: 543.624
• InChiKey: VPUKSHGFQCSSIY-OVAHNPOGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.81
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  93.1
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• METHODS OF ADMINISTERING (4AR,10AR)-1-N-PROPYL-1,2,3,4,4A,5,10,10A-OCTAHYDROBENZO [G] QUINOLINE-6,7-DIOL AND RELATED COMPOUNDS ACROSS THE ORAL MUCOSA, THE NASAL MUCOSA OR THE SKIN AND PHARMACEUTICAL COMPOSITIONS THEREOF
  申请人：Wikström Håkan

  公开号：US20120077836A1

  公开（公告）日：2012-03-29

  Disclosed are pharmaceutical compositions and methods for the administration of (4aR,10aR)-1-n-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinoline-6,7-diol or a pharmaceutically acceptable salt thereof and related compounds for the treatment of neurological disorder such as Parkinson's disease and restless leg syndrome.

  本发明涉及药物组合物及其给药方法，用于治疗神经系统疾病，例如帕金森病和不安腿综合征，所述组合物包括(4aR,10aR)-1-正丙基-1,2,3,4,4a,5,10,10a-八氢苯并[g]喹啉-6,7-二酚或其药学上可接受的盐和相关化合物。
• METHODS OF ADMINISTERING (4AR, 1OAR)-I-N-PROPYL-I, 2,3,4A7 S1IO7 IOA-OCTAHYDROBENZO ÝG¨QUINOLINE-6,7-DIOL AND RELATED COMPOUNDS ACROSS THE ORAL MUCOSA, THE NASAL MUCOSA OR THE SKIN AND PHARMACEUTICAL COMPOSITIONS THEREOF
  申请人：H. Lundbeck A/S

  公开号：EP2400955A1

  公开（公告）日：2012-01-04