4-{[3-chloro-5-methyl-3'-({[3-(4-morpholinyl) propyl]amino}methyl) [1,1'-biphenyl]-4-yl]amino}-7-[3-({[3-(4-morpholinyl) propyl]amino}methyl) phenyl]-3-quinolinecarbonitrile | 364791-53-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-{[3-chloro-5-methyl-3'-({[3-(4-morpholinyl) propyl]amino}methyl) [1,1'-biphenyl]-4-yl]amino}-7-[3-({[3-(4-morpholinyl) propyl]amino}methyl) phenyl]-3-quinolinecarbonitrile
• 英文别名: 4-[2-Chloro-6-methyl-4-[3-[(3-morpholin-4-ylpropylamino)methyl]phenyl]anilino]-7-[3-[(3-morpholin-4-ylpropylamino)methyl]phenyl]quinoline-3-carbonitrile
• CAS: 364791-53-7
• 化学式: C₄₅H₅₂ClN₇O₂
• 分子量: 758.407
• InChiKey: JFMUCLXEPXRVTJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  55
• 可旋转键数：
  16
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  97.7
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS
  申请人：Wyeth

  公开号：EP1268431B1

  公开（公告）日：2007-08-29
• 3-Cyanoquinolines,3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors
  申请人：Wyeth

  公开号：US20040176602A1

  公开（公告）日：2004-09-09

  This invention provides compounds of Formula (I), having the structure 1 where T, Z, X, A, R 1 , R 2a , R 2b , R 2c , R 3 , R 4 , and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of osteoporosis and polycystic kidney disease.
• PHARMACEUTICAL COMPOSITIONS OF AN SRC KINASE INHIBITOR AND AN AROMATASE INHIBITOR
  申请人：Zacharchuk Charles Michael

  公开号：US20100069340A1

  公开（公告）日：2010-03-18

  This invention is directed to a pharmaceutical composition comprising an Src kinase inhibitor and an aromatase inhibitor, and to the use of a combination of an Src kinase inhibitor and an aromatase inhibitor in treating abnormal cell proliferation and abnormal angiogenesis associated with cancer, including breast cancer.
• US6521618B2
  申请人：——

  公开号：US6521618B2

  公开（公告）日：2003-02-18
• US6689772B1
  申请人：——

  公开号：US6689772B1

  公开（公告）日：2004-02-10