2,2'-(thiophen-2-ylmethylene)bis[3-methyl-6,7-dihydrobenzofuran-4(5H)-one] | 1632461-86-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,2'-(thiophen-2-ylmethylene)bis[3-methyl-6,7-dihydrobenzofuran-4(5H)-one]
• CAS: 1632461-86-9
• 化学式: C₂₃H₂₂O₄S
• 分子量: 394.491
• InChiKey: YPBJYDDUZGOICZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.77
• 重原子数：
  28.0
• 可旋转键数：
  3.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  60.42
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  2-噻吩甲醛 、 3-methyl-6,7-dihydrobenzofuran-4(5H)-one 以 neat (no solvent) 为溶剂， 反应 0.03h， 以83%的产率得到2,2'-(thiophen-2-ylmethylene)bis[3-methyl-6,7-dihydrobenzofuran-4(5H)-one]
  参考文献：
  名称：

  Facile and eco-friendly synthesis of bis(tetrahydrobenzofuran-2-yl)alkane derivatives catalyzed by H2S04.SiO2 under solvent-free conditions

  摘要：

  A series of bis(2-tetrahydrobenzofuranyl)alkanes were efficiently prepared in high yields (69-98%) from 3-methyl-6,7-dihydrobenzofuran-4(5H)-ones and aldehydes under solvent-free conditions. The eco-friendly condensation reaction was smoothly catalyzed by H2SO4 center dot SiO2 (30% w/w) in three minutes at 90 degrees C, and the catalyst could also be recycled up to nine successive cycles without significant loss in catalytic activity.

  DOI：

  10.3998/ark.5550190.p008.468