3,6-di(6-hydroxymethyl-2-pyridyl)pyridazine | 188394-36-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3,6-di(6-hydroxymethyl-2-pyridyl)pyridazine
• 英文别名: [Pyridazine-3,6-diyldi(pyridine-6,2-diyl)]dimethanol；[6-[6-[6-(hydroxymethyl)pyridin-2-yl]pyridazin-3-yl]pyridin-2-yl]methanol
• CAS: 188394-36-7
• 化学式: C₁₆H₁₄N₄O₂
• 分子量: 294.313
• InChiKey: CNMBICRVIRUMPH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  92
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3,6-di(6-hydroxymethyl-2-pyridyl)pyridazine 在 manganese(IV) oxide 、 溶剂黄146 作用下， 以 乙醇 、 氯仿 为溶剂， 反应 72.0h， 生成 3-[6-(4-iminomethoxybenzene)-2-pyridyl]-6-[(6-hydroxymethyl-2-pyridyl)]pyridazine
  参考文献：
  名称：

  易于进入带有用于氢键的悬垂伯醇功能的席夫碱分子

  摘要：

  以MnO 2 为氧化剂制备了一系列单氧化吡啶、联吡啶、三联吡啶和吡啶/哒嗪骨架。相应的席夫碱是用带有各种功能的芳香胺或脂肪胺制备的，例如链烷烃链、末端丙烯酸酯和第二个氮原子。各种柔性系链已用于双位配体合成。这些配体为较短的链形成双核螺旋。由 CH 2 -CH 2 桥制备的双核铜 (I) 配合物通过残余伯醇基团的氢键网络以固态聚集。对于较长的间隔物，双位配体包裹在单个铜 (I) 中心周围，形成单核复合物。这项工作的一个显着优点是它允许制备保留羟甲基功能的配体和配合物，

  DOI：

  10.1055/s-2004-834943
• 作为产物：
  描述：

  2-[(2-tetrahydro-2H-pyranyloxy)methyl]-6-(tributylstannyl)-pyridine 在 四(三苯基膦)钯 对甲苯磺酸 作用下， 以 甲醇 、 甲苯 为溶剂， 生成 3,6-di(6-hydroxymethyl-2-pyridyl)pyridazine
  参考文献：
  名称：

  Double Subroutine Self-Assembly; Spontaneous Generation of a Nanocyclic Dodecanuclear Cu1 Inorganic Architecture

  摘要：

  AbstractThe newly synthesised ligand 2 combines binding components known to undergo specific and distinct self‐assembly processes with Cu1 ions. It complexes Cu1 to form, in almost quantitative yield, a large inorganic architecture 1 made up from four ligand molecules and twelve metal ions. The structure of 1 was ascertained by X‐ray radiocrystallography as well as by NMR spectroscopy and electrospray mass spectrometry. It consists of a macrocycle of nanometric dimension with an external diameter of 28 Å; the central cavity has a diameter of 11 Å, which contains four PF−6 anions as well as solvent molecules. The spontaneous formation of 1 results from a self‐assembly process based on a “program” combining two assembly subroutines, each specific to one of the ligand subunits. Self‐assembly through double or, more generally, multiple subroutines can be used to generate a wide variety of highly complex inorganic supramolecular architectures by combination of two or more assembly processes.

  DOI：

  10.1002/chem.19970030116

文献信息

• Selective Oxidation of a Single Primary Alcohol Function in Oligopyridine Frameworks
  作者：Raymond Ziessel、Patrick Nguyen、Laurent Douce、Michèle Cesario、Claude Estournes

  DOI：10.1021/ol0491843

  日期：2004.8.1

  A variety of mono-oxidized pyridine, bipyridine, terpyridine, and pyridine/pyridazine are readily prepared under mild conditions using Pyrolusite MnO2. This phase has been characterized by means of X-ray powder diffraction and scanning electron microscopy. The oxidative activity is in keeping with the nature, morphology, and surface area of the MnO2 reagent.
• Double Subroutine Self-Assembly; Spontaneous Generation of a Nanocyclic Dodecanuclear Cu1 Inorganic Architecture
  作者：Daniel P. Funeriu、Jean-Marie Lehn、Gerhard Baum、Dieter Fenske

  DOI：10.1002/chem.19970030116

  日期：1997.1

  AbstractThe newly synthesised ligand 2 combines binding components known to undergo specific and distinct self‐assembly processes with Cu1 ions. It complexes Cu1 to form, in almost quantitative yield, a large inorganic architecture 1 made up from four ligand molecules and twelve metal ions. The structure of 1 was ascertained by X‐ray radiocrystallography as well as by NMR spectroscopy and electrospray mass spectrometry. It consists of a macrocycle of nanometric dimension with an external diameter of 28 Å; the central cavity has a diameter of 11 Å, which contains four PF−6 anions as well as solvent molecules. The spontaneous formation of 1 results from a self‐assembly process based on a “program” combining two assembly subroutines, each specific to one of the ligand subunits. Self‐assembly through double or, more generally, multiple subroutines can be used to generate a wide variety of highly complex inorganic supramolecular architectures by combination of two or more assembly processes.
• An Easy Entry into Schiff Base Molecules Bearing a Pendant Primary Alcohol Function for Hydrogen Bonding
  作者：Raymond Ziessel、Patrick Nguyen

  DOI：10.1055/s-2004-834943

  日期：——

  2 as oxidant. Corresponding Schiff bases were prepared with aromatic or aliphatic amines carrying various functions such as paraffin chains, terminal acrylates and a second nitrogen atom. Various flexible tethers have been used for the ditopic ligands synthesis. These ligands formed dinuclear helicates for the shorter chains. The dinuclear copper(I) complex prepared from the CH 2 -CH 2 bridge is aggregated

  以MnO 2 为氧化剂制备了一系列单氧化吡啶、联吡啶、三联吡啶和吡啶/哒嗪骨架。相应的席夫碱是用带有各种功能的芳香胺或脂肪胺制备的，例如链烷烃链、末端丙烯酸酯和第二个氮原子。各种柔性系链已用于双位配体合成。这些配体为较短的链形成双核螺旋。由 CH 2 -CH 2 桥制备的双核铜 (I) 配合物通过残余伯醇基团的氢键网络以固态聚集。对于较长的间隔物，双位配体包裹在单个铜 (I) 中心周围，形成单核复合物。这项工作的一个显着优点是它允许制备保留羟甲基功能的配体和配合物，