(3-Imidazol-1-yl-propyl)-carbamic acid 1-(4-chloro-benzenesulfonyl)-1,2,3,4-tetrahydro-quinolin-2-yl methyl ester | 497958-03-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (3-Imidazol-1-yl-propyl)-carbamic acid 1-(4-chloro-benzenesulfonyl)-1,2,3,4-tetrahydro-quinolin-2-yl methyl ester
• 英文别名: [1-(4-chlorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-2-yl]methyl N-(3-imidazol-1-ylpropyl)carbamate
• CAS: 497958-03-9
• 化学式: C₂₃H₂₅ClN₄O₄S
• 分子量: 488.995
• InChiKey: QKRRZHRJIPXFCM-UHFFFAOYSA-N

物化性质

• 密度：
  1.38±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Novel gamma secretase inhibitors
  申请人：SCHERING CORPORATION

  公开号：US20030135044A1

  公开（公告）日：2003-07-17

  This invention discloses novel gamma secretase inhibitors of the formula: 1 wherein: R 1 is a substituted aryl or substituted heteroaryl group; R 2 is an R 1 group, alkyl, —X(CO)Y, —(CR 3 2 ) 1-4 X(CO)Y; each R 3A is independently H or alkyl; X is —O—, —NH, or —N-alkyl; and Y is —NR 6 R 7 , or —N(R 3 )(CH 2 ) 2-6 NR 6 R 7 . Also disclosed is a method of treating Alzheimer's Disease.

  本发明揭示了新型伽马分泌酶抑制剂的化学式：1其中：R1是取代芳基或取代杂环芳基基团；R2是R1基团、烷基、—X(CO)Y、—(CR32)1-4X(CO)Y；每个R3A独立地是氢或烷基；X是—O—、—NH或—N-烷基；而Y是—NR6R7或—N(R3)(CH2)2-6NR6R7。还公开了治疗阿尔茨海默病的方法。
• NOVEL GAMMA SECRETASE INHIBITORS
  申请人：SCHERING CORPORATION

  公开号：EP1492765A2

  公开（公告）日：2005-01-05
• US6683091B2
  申请人：——

  公开号：US6683091B2

  公开（公告）日：2004-01-27
• [EN] NOVEL GAMMA SECRETASE INHIBITORS<br/>[FR] NOUVEAUX INHIBITEURS DE GAMMA-SECRETASE
  申请人：SCHERING CORP

  公开号：WO2003014075A2

  公开（公告）日：2003-02-20

  This invention discloses novel gamma secretase inhibitors of the formula:(Chemical formula should be inserted here as it appears on abstract in paper form)wherein: R1 is a substituted aryl or substituted heteroaryl group; R2 is an R1 group, alkyl, -X(CO)Y, -(CR32)1-4X(CO)Y; each R3A is independently H or alkyl; X is -O-, -NH, or -N-alkyl; and Y is -NR6R7, or -N(R3)(CH2)2-6NR6R7. Also disclosed is a method of treating Alzheimer s Disease.