D-Ribonsaeure-methylester | 20769-97-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: D-Ribonsaeure-methylester
• 英文别名: Methyl-D-ribonat；Methoxyribose；methyl (2R,3R,4R)-2,3,4,5-tetrahydroxypentanoate
• CAS: 20769-97-5
• 化学式: C₆H₁₂O₆
• 分子量: 180.158
• InChiKey: JWILWRLEBBNTFH-UOWFLXDJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  107
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  甲醇 、 D-arabinoic acid calcium salt 在 硫酸 作用下， 生成 D-Ribonsaeure-methylester
  参考文献：
  名称：

  Benzyliden-verbindungen der pentonsäuren und pentonsäure-lactone

  摘要：

  DOI：

  10.1016/s0008-6215(00)81432-9

文献信息

• PROCESS FOR PRODUCING PENTOSE-5-PHOSPHATE ESTER
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1690946A1

  公开（公告）日：2006-08-16

  A pentose such as ribose, arabinose, 2-deoxyribose, 1-methoxy-2-deoxyribose or the like is reacted with a phosphoric acid donor such as a pyrophosphoric acid or an alkali metal salt thereof in the presence of an acid phosphatase. Thus, a pentose-5-phosphate ester can be produced, such as a ribose-5-phosphate ester, an arabinose-5-phosphate ester, a 2-deoxyribose-5-phosphate ester, a 1-methoxy-2-deoxyribose-5-phosphate ester or the like.

  核糖、阿拉伯糖、2-脱氧核糖、1-甲氧基-2-脱氧核糖等戊糖在酸性磷酸酶的作用下与磷酸供体（如焦磷酸或其碱金属盐）反应。这样，就可以生成戊糖-5-磷酸酯，如核糖-5-磷酸酯、阿拉伯糖-5-磷酸酯、2-脱氧核糖-5-磷酸酯、1-甲氧基-2-脱氧核糖-5-磷酸酯等。
• Nucleic acid amplification in the presence of modified randomers
  申请人：Roche Diagnostics GmbH

  公开号：EP2103693A1

  公开（公告）日：2009-09-23

  The present invention is directed to a composition comprising a DNA Polymerase which is preferably thermostable, Deoxynucleotides, at least one primer oligonucleotide or a pair of amplification primers, and randomized 5-8 mer oligonucleotide, characterized in that said oligonucleotide comprises a modification with an organic hydrophobic moiety Such a composition is specifically useful for performing hot start PCR.

  本发明涉及一种组合物，该组合物包含 DNA 聚合酶（最好是恒温的）、脱氧核苷酸、至少一种引物寡核苷酸或一对扩增引物，以及随机化的 5-8 mer 寡核苷酸，其特征在于所述寡核苷酸包含有机疏水分子修饰。
• Polyanion for improved nucleic acid amplification
  申请人：Roche Diagnostics GmbH

  公开号：EP2163556A1

  公开（公告）日：2010-03-17

  The present inmvention is directed to a novel chemical compound comprising the structure [X x - (CH2) m - Phosphate - Yy] n, characterized in that 3 ≤ m ≤ 6, 30 ≤ n ≤ 60, each x and y is independently from each other 0 or 1, each X and Y is independently from each other any photometrically measurable entity; provided that the terminal X can also be an - OH group or a Phosphate group, and further provided that the terminal Y can also be an -OH group. Such a compound can be used as a suitable hot start additive for PCR based amplification of nucleic acids.

  本发明涉及一种新型化合物，其结构为[X x - (CH2) m - 磷酸酯 - Yy] n，其特征在于：3 ≤ m ≤ 6，30 ≤ n ≤ 60，每个 x 和 y 相互独立地为 0 或 1，每个 X 和 Y 相互独立地为任何可光度测量的实体；条件是末端 X 也可以是-OH 基团或磷酸酯基团，进一步条件是末端 Y 也可以是-OH 基团。这种化合物可用作适当的热启动添加剂，用于基于 PCR 的核酸扩增。
• Decoy probes
  申请人：——

  公开号：US20020038016A1

  公开（公告）日：2002-03-28

  The present invention features inhibitors of target-independent amplification and the use of such inhibitors for enhancing an amplification protocol. The inhibitors are believed to enhance an amplification protocol by inhibiting the ability of one or more nucleic acid polymerases to use nucleic acid in a polymerase reaction in the absence of target nucleic acid.

  本发明的特点是靶标无关扩增抑制剂以及使用这种抑制剂来增强扩增方案。这些抑制剂可抑制一种或多种核酸聚合酶在没有目标核酸的情况下在聚合酶反应中使用核酸的能力，从而增强扩增方案。
• Method for enhancing amplification of a target nucleic acid sequence
  申请人：——

  公开号：US20030157547A1

  公开（公告）日：2003-08-21

  The present invention features inhibitors of target-independent amplification and the use of such inhibitors for enhancing an amplification protocol. The inhibitors are believed to enhance an amplification protocol by inhibiting the ability of one or more nucleic acid polymerases to use nucleic acid in a polymerase reaction in the absence of target nucleic acid.

  本发明的特点是靶标无关扩增抑制剂以及使用这种抑制剂来增强扩增方案。这些抑制剂可抑制一种或多种核酸聚合酶在没有目标核酸的情况下在聚合酶反应中使用核酸的能力，从而增强扩增方案。