非诺洛芬钙盐二水合物 | 71720-56-4

• 物质功能分类: 原料药 - 解热镇痛药 - 非甾抗炎药
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 非诺洛芬钙盐二水合物
• 中文别名: 2-(3-苯氧基苯)丙酸钙盐二水；非诺洛芬钙；非诺洛芬钙二水合物
• 英文名称: Fenoprofen calcium salt hydrate
• CAS: 71720-56-4
• 化学式: C15H16CaO4
• 分子量: 300.36
• InChiKey: TUWXDZBTJRWTMJ-UHFFFAOYSA-N

物化性质

• 溶解度：
  DMF：33mg/mL； DMSO：33mg/mL； DMSO:PBS (pH 7.2)(1:8)：0.11 mg/mL

计算性质

• 辛醇/水分配系数(LogP)：
  2.46
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  47.5
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• WGK Germany：
  3
• 危险性防范说明：
  P280
• 危险性描述：
  H302+H312+H332

制备方法与用途

生物活性
非诺洛芬钙水合物（Fenoprofen Calcium hydrate）是一种非甾体类抗炎化合物。

靶点：
COX

文献信息

• Geminallyl di-substituted nsaid derivatives as abeta 42 lowering agents
  申请人：Munoz Benito

  公开号：US20060063937A1

  公开（公告）日：2006-03-23

  The present invention encompasses compounds of Formula I (I) or pharmaceutically acceptable salts thereof, wherein A is the base molecule of a propionic acid or acetic acid NSAID, or a derivative thereof, X is —CO 2 H, 1H-tetrazol-5-yl or 2H-tetrazol-5-yl and R 1 and R 2 are each independently selected from the group consisting of: C 1-6 alkyl and C 3-6 cycloalkyl, as well as pharmaceutical composition comprising said compounds and methods of using said compounds. The compounds of the present invention lower the level of Aβ 42 and are therefore useful for preventing, delaying or reversing the progression of Alzheimer s Disease.

  本发明涵盖公式I（I）的化合物或其药学上可接受的盐，其中A是丙酸或乙酸非甾体抗炎药的基本分子或其衍生物，X为-CO2H，1H-四唑-5-基或2H-四唑-5-基，R1和R2各自独立地选自以下组：C1-6烷基和C3-6环烷基，以及包括所述化合物的制药组合物和使用所述化合物的方法。本发明的化合物降低Aβ42的水平，因此有助于预防、延缓或逆转阿尔茨海默病的进展。
• EP1587798A4
  申请人：——

  公开号：EP1587798A4

  公开（公告）日：2007-06-27
• GEMINALLY DI-SUBSTITUTED NSAID DERIVATIVES AS ABETA 42 LOWERING AGENTS
  申请人：Merck & Co., Inc.

  公开号：EP1587798A2

  公开（公告）日：2005-10-26
• US7332516B2
  申请人：——

  公开号：US7332516B2

  公开（公告）日：2008-02-19
• [EN] GEMINALLY DI-SUBSTITUTED NSAID DERIVATIVES AS ABETA 42 LOWERING AGENTS<br/>[FR] DERIVES DE NSAID A DISUBSTITUTION GEMINALE SERVANT D'AGENTS REDUCTEURS DE ABETA 42
  申请人：MERCK & CO INC

  公开号：WO2004064771A2

  公开（公告）日：2004-08-05

  The present invention encompasses compounds of Formula I (I) or pharmaceutically acceptable salts thereof, wherein A is the base molecule of a propionic acid or acetic acid NSAID, or a derivative thereof, X is -CO2H, 1H-tetrazol-5-yl or 2H-tetrazol-5-yl and R1 and R2 are each independently selected from the group consisting of: C1-6alkyl and C3-6cycloalkyl, as well as pharmaceutical composition comprising said compounds and methods of using said compounds. The compounds of the present invention lower the level of Aß42 and are therefore useful for preventing, delaying or reversing the progression of Alzheimer s Disease.