Gly-Ala-Val-OH | 121428-48-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Gly-Ala-Val-OH
• 英文别名: Gly-Ala-Leu；GAV；H₂N-Gly-Ala-Val-OH；Glycyl-alanyl-valine；(2S)-2-[[(2S)-2-[(2-aminoacetyl)amino]propanoyl]amino]-3-methylbutanoic acid
• CAS: 121428-48-6
• 化学式: C₁₀H₁₉N₃O₄
• 分子量: 245.279
• InChiKey: JRDYDYXZKFNNRQ-XPUUQOCRSA-N

物化性质

• 沸点：
  565.0±45.0 °C(Predicted)
• 密度：
  1?+-.0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.7
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  122
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  苄氧羰基-甘氨酰-丙氨酸 在 palladium on activated charcoal 、 氢气 、 氯甲酸乙酯 、 三乙胺 、 sodium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 水 、 丙酮 为溶剂， 反应 13.25h， 生成 Gly-Ala-Val-OH
  参考文献：
  名称：

  Rational Design of Small Peptides for Optimal Inhibition of Cyclooxygenase-2: Development of a Highly Effective Anti-Inflammatory Agent

  摘要：

  Among the small peptides 2-31, (H)Gly-Gly-Phe-Leu(OMe) (30) reduced prostaglandin production of COX-2 with an IC50 of 60 nM relative to 6000 nM for COX-1. The 5 mg kg-1 dose of compound 30 rescued albino mice by 80% from capsaicin-induced paw licking and recovered it by 60% from carrageenan-induced inflammation. The mode of action of compound 30 for targeting COX-2, iNOS, and VGSC was investigated by using substance P, l-arginine, and veratrine, respectively, as biomarkers. The interactions of 30 with COX-2 were supported by isothermal calorimetry experiments showing a Ka of 6.10 +/- 1.10 X 104 M-1 and Delta G of -100.3 kJ mol-1 in comparison to a Ka 0.41 X 103 +/- 0.09 M-1 and Delta G of -19.2 +/- 0.06 kJ mol(-1) for COX-1. Moreover, compound 30 did not show toxicity up to a 2000 mg kg(-1) dose. Hence, we suggest peptide 30 as a highly potent and promising candidate for further development into an anti-inflammatory drug.

  DOI：

  10.1021/acs.jmedchem.6b00134

文献信息

• Determination of Peptide Backbone Torsion Angles Using Double-Quantum Dipolar Recoupling Solid-State NMR Spectroscopy
  作者：Manish A. Mehta、Matthew T. Eddy、Seth A. McNeill、Frank D. Mills、Joanna R. Long

  DOI：10.1021/ja074244w

  日期：2008.2.1

  Several approaches for utilizing dipolar recoupling solid-state NMR (ssNMR) techniques to determine local structure at high resolution in peptides and proteins have been developed. However, many of these techniques measure only one torsion angle or are accurate for only certain classes of secondary structure. Additionally, the efficiency with which these dipolar recoupling experiments suppress the

  已经开发了几种利用偶极耦合固态核磁共振 (ssNMR) 技术在肽和蛋白质中以高分辨率确定局部结构的方法。然而，这些技术中的许多技术仅测量一个扭转角或仅对某些类别的二级结构是准确的。此外，这些偶极再耦合实验在高磁场强度下抑制化学位移各向异性 (CSA) 有害影响的效率各不相同。与无窗序列 (DRAWS) 的偶极耦合已被证明是一种有效的脉冲序列，可用于激发沿肽骨架的相邻羰基碳之间的双量子 (DQ) 相干性。通过允许这种 DQ 一致性发展，可以测量 CSA 张量的相对方向，然后使用此信息来确定拉马钱德兰扭转角 phi 和 psi。在这里，我们探讨了在解释 DQ-DRAWS 数据时所做假设的准确性，并证明了它们在测量对应于各种二级结构的扭转角时的保真度，而不管氢键模式如何。展示了如何简单地选择同位素标记和实验条件，无需任何先验知识即可准确测量主链二级结构。这种方法对于确定螺旋结构更加敏感，并且与其
• POLISHING COMPOUND FOR SEMICONDUCTOR CONTAINING PEPTIDE
  申请人：Seimi Chemical Co., Ltd.

  公开号：EP1235261A1

  公开（公告）日：2002-08-28

  A polishing compound and a polishing method are provided, whereby in a CMP process in a process for production of a semiconductor device, a metal layer and/or a barrier layer, etc., can be polished while suppressing excessive oxidation of the metal layer, and the polishing rate can be adjusted depending upon the application. A polishing compound comprising polishing abrasive grains and a peptide, a polishing compound slurry having such a polishing compound suspended in an aqueous medium, preferably together with an oxidizing agent and preferably at a pH of at least 7, and a method for polishing a metal layer of e.g. Cu and/or a barrier layer, formed on a semiconductor substrate, by polishing with an abrasive cloth of a CMP apparatus having such a polishing compound slurry supported thereon, are disclosed.

  本发明提供了一种抛光化合物和一种抛光方法，从而在半导体器件生产工艺中的CMP工序中，可以在抛光金属层和/或阻挡层等的同时抑制金属层的过度氧化，并且可以根据应用调整抛光速率。 本发明公开了一种由抛光磨粒和肽组成的抛光化合物、一种将这种抛光化合物悬浮于水性介质（最好与氧化剂一起且 pH 值最好至少为 7）中的抛光化合物浆料，以及一种通过使用支撑有这种抛光化合物浆料的 CMP 设备的砂布对形成于半导体基板上的铜等金属层和/或阻挡层进行抛光的方法。
• Composition containing a penem or carbapenem antibiotic
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0226304B1

  公开（公告）日：1991-08-28
• Kumar, I. M. Krishna; Mathew, Beena, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003, vol. 42, # 4, p. 916 - 920
  作者：Kumar, I. M. Krishna、Mathew, Beena

  DOI：——

  日期：——
• HAIR TREATMENT COMPOSITIONS
  申请人：Unilever PLC

  公开号：EP1959919A1

  公开（公告）日：2008-08-27