2-[(E)-(quinolin-3-ylimino)methyl]phenolatoacetatoaquocopper(II) | 1388641-71-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-[(E)-(quinolin-3-ylimino)methyl]phenolatoacetatoaquocopper(II)
• 英文别名: [Cu(QMP)(CH3OO)(H2O)]
• CAS: 1388641-71-1
• 化学式: C₁₈H₁₆CuN₂O₄
• 分子量: 387.882
• InChiKey: UEIAGXMZIVFQAQ-IAHIQKNASA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  1-[(E)-(quinolin-3-ylimino)methyl]phenol 、 水 、 copper diacetate 以 甲醇 为溶剂， 生成 2-[(E)-(quinolin-3-ylimino)methyl]phenolatoacetatoaquocopper(II)
  参考文献：
  名称：

  Synthesis, characterization and distinct butyrylcholinesterase activities of transition metal complexes of 2-[(E)-(quinolin-3-ylimino)methyl]phenol

  摘要：

  2-[(E)-(Quinolin-3-ylimino) methyl] phenol (H-QMP) was synthesized by condensing salicylaldehyde with 2-aminoquinoline and fully characterized by mass spectrometry, H-1 and C-13{H-1} NMR, and IR spectroscopies. The metal complexes [M(QMP)(OAc)]H2O where M = Cu(II) and Zn(II) and [M(QMP)(2)] where M = Ni and Co(II) were prepared from the metal acetates. All transition metal complexes were assigned geometries based on the UV-Vis spectra, conductivity and magnetic susceptibilities. [M(QMP)(2)], {where M = Ni and Co(II)}, were further characterized by single crystal X-ray diffraction and were found to be pseudo-octahedral with interquinoline interaction to the metal center. The complexes were screened for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Only cobalt and copper containing complexes were found to be active against BChE with IC50 = 69 +/- 0.0112 and 5 +/- 0.0004 mu M +/- SEM, respectively. Surprisingly no activity was observed for AChE, therefore selective BChE inhibition was observed for copper and cobalt complexes only. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2012.04.036