(4-chloro-3-imidazol-1-yl-phenyl)-(3-propyl-piperidin-3-yl)-methanone | 1202180-80-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (4-chloro-3-imidazol-1-yl-phenyl)-(3-propyl-piperidin-3-yl)-methanone
• 英文别名: (4-Chloro-3-imidazol-1-ylphenyl)-(3-propylpiperidin-3-yl)methanone
• CAS: 1202180-80-0
• 化学式: C₁₈H₂₂ClN₃O
• 分子量: 331.845
• InChiKey: FKAMFTVPPLSCTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  46.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Aryl pyrrolidinyl and piperidinyl ketone derivatives and uses thereof
  申请人：Iyer Pravin

  公开号：US20090318493A1

  公开（公告）日：2009-12-24

  Aryl and heteroaryl ketone compounds substituted with pyrrolidines and piperidines, that modulate serotonin norepinephrine and/or dopamine neurotransmission. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.

  含有吡咯烷和哌啶取代基的芳基和杂芳基酮化合物，可调节5-羟色胺、去甲肾上腺素和/或多巴胺神经传导。还提供了药物组合物、使用方法和合成这些化合物的方法。
• [EN] ARYL KETONE AS MRI<br/>[FR] ARYLE CÉTONE UTILISÉ INHIBITEUR DE LA RECAPTURE DES MONOAMINES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2009153178A2

  公开（公告）日：2009-12-23

  This invention pertains to aryl pyrrolidinyl and piperidinyl ketone compounds of formula (I) wherein R1 and R2 are as described herein, as well as pharmaceutically acceptable salts and esters thereof, and methods for using the same. In particular, compounds of the present invention are useful for treatment of diseases associated with monoamine reuptake inhibition.