2-acetamido-2-deoxy-D-ribose | 24695-39-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-acetamido-2-deoxy-D-ribose
• 英文别名: 2-acetamido-2-deoxy-D-ribopyranoside；2-Acetamino-2-desoxy-D-ribose；N-[(3R,4S,5R)-2,4,5-trihydroxyoxan-3-yl]acetamide
• CAS: 24695-39-4；117771-11-6；117771-21-8
• 化学式: C₇H₁₃NO₅
• 分子量: 191.184
• InChiKey: CPNJOFOGZRFOSG-RKEPMNIXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.5
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  99
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-acetamido-3-deoxy-1,2:5,6-di-O-isopropylidene-α-D-allofuranose 在 盐酸 、 过氧丙酸 作用下， 以 甲醇 为溶剂， 反应 3.0h， 生成 2-acetamido-2-deoxy-D-ribose
  参考文献：
  名称：

  320. 3-乙酰胺基-3-脱氧-D-阿洛糖二乙基二硫缩醛及其过氧化丙酸的氧化作用

  摘要：

  DOI：

  10.1039/jr9610001643

文献信息

• A STEREOSELECTIVE SYNTHESIS OF 2-AMINO-2-DEOXY-D-ARABINOSE AND -D-RIBOSE
  作者：Teruaki Mukaiyama、Tetsuo Miwa、Takashi Nakatsuka

  DOI：10.1246/cl.1982.145

  日期：1982.2.5

  Two amino pentoses, 2-acetamido-2-deoxy-d-arabinose and -d-ribose, are conveniently synthesized from 2-amino-2-deoxy-d-pentonic acid derivatives, obtained by the stereoselective reaction of the chiral imine 1 with 2,3-O-isopropylidene-d-glyceraldehyde.

  通过手性亚胺 1 与 2,3-O-异亚丙基-d-甘油醛的立体选择性反应，可方便地从 2-氨基-2-脱氧-d-戊酸衍生物合成两种氨基戊糖，即 2-乙酰氨基-2-脱氧-d-阿拉伯糖和-d-核糖。
• Topical composition comprising N-acetylaldosamines or N-acetylamino acids
  申请人：Yu, Ruey J., Dr.

  公开号：EP1639994A2

  公开（公告）日：2006-03-29

  Compositions comprising N-acetyl-aldosamines, N-acetylamino acids, and related N-acetyl compounds are useful to alleviate or improve various cosmetic conditions and dermatological disorders, including changes or damage to skin, nail and hair associated with intrinsic aging and/or extrinsic aging, as well as changes or damage caused by extrinsic factors. N-acetyl-aldosamines, N-acetylamino acids, and related N-acetyl composition may further comprise a cosmetic, pharmaceutical or other topical agent to enhance or create synergetic effects.

  包含 N-乙酰-醛胺，N-乙酰基氨基酸和相关 N-乙酰基化合物的组合物可用于缓解或改善各种美容状况和皮肤病，包括与内在老化和/或外在老化相关的皮肤、指甲和头发的变化或损伤，以及由外在因素引起的变化或损伤。N-acetyl-aldosamines, N-acetylamino acids 和相关的 N-acetyl 组合物可进一步包含化妆品、药物或其他外用制剂，以增强或产生协同效应。
• Topical composition comprising n-acetylaldosamines or n-acetylamino acids
  申请人：Yu, Ruey J.

  公开号：EP2080504A2

  公开（公告）日：2009-07-22

  Compositions comprising N-acetyl-aldosamines, N-acetylamino acids, and related N-acetyl compounds are useful to alleviate or improve various cosmetic conditions and dermatological disorders, including changes or damage to skin, nail and hair associated with intrinsic aging and/or extrinsic aging, as well as changes or damage caused by extrinsic factors. N-acetyl-aldosamines, N-acetylamino acids, and related N-acetyl composition may further comprise a cosmetic, pharmaceutical or other topical agent to enhance or create synergetic effects.

  包含 N-乙酰-醛胺，N-乙酰基氨基酸和相关 N-乙酰基化合物的组合物可用于缓解或改善各种美容状况和皮肤病，包括与内在老化和/或外在老化相关的皮肤、指甲和头发的变化或损伤，以及由外在因素引起的变化或损伤。N-acetyl-aldosamines, N-acetylamino acids 和相关的 N-acetyl 组合物可进一步包含化妆品、药物或其他外用制剂，以增强或产生协同效应。
• Enlargement of mucocutaneous or cutaneous organs and sites with topical compositions
  申请人：Yu J. Ruey

  公开号：US20050171194A1

  公开（公告）日：2005-08-04

  Compositions comprising a hydroxycarboxylic acid, N-acyl-aldosamine, N-acylamino acid or related compound on topical application are beneficial to plump and pout lips, enhance and firm eyelids, enlarge and augment breasts, elongate and expand penis. Because of antioxidant property, certain hydroxycarboxylic acids, N-acyl-aldosamines, N-acylamino acids and related compounds also are useful for topical administration to prevent occurrence of breast cancer or other forms of tumors and cancers.

  由羟基羧酸、N-酰基-醛糖胺、N-酰基氨基酸或相关化合物组成的组合物在局部使用时有利于丰满嘴唇、增强和紧实眼睑、增大和隆起乳房、拉长和扩张阴茎。由于具有抗氧化性，某些羟基羧酸、N-酰基醛胺和 N-酰基氨基酸及相关化合物还可用于局部用药，以预防乳腺癌或其他形式的肿瘤和癌症的发生。
• TOPICAL COMPOSITION COMPRISING N-ACETYLALDOSAMINES OR N-ACETYLAMINO ACIDS
  申请人：Yu, Ruey J., Dr.

  公开号：EP1143925A1

  公开（公告）日：2001-10-17