outcome, allowing for the selective preparation of 2,5-cis- or 2,5-trans-3-sulfinyl disubstituted dihydropyrroles from a common sulfinamide intermediate. Further research on halocyclization conditions has also yielded a stereoselective synthesis of trisubstituted vinyl aziridines from these chiral sulfinamides, simply by changing the halogenating agent.
非对映选择性地将
锂化的
乙烯基亚砜添加到对映体纯的亚
磺胺中,可直接获得各种烯丙基亚磺
酰胺类化合物,产率高,选择性好。这些加合物是功能不同的顺式和反式二氢
吡咯的关键前体。环化之前对氮上保护基的调节对立体
化学结果具有重大影响,从而可以选择性地制备2,5-顺式或2,5-反式来自普通亚磺酰胺中间体的-3-亚磺酰基二取代二氢
吡咯。对卤代环化条件的进一步研究也仅通过改变卤化剂就可以从这些手性亚磺酰胺立体选择性地合成三取代
乙烯基氮丙啶。