4-[(3-hydroxyphenoxy)methyl]styrene | 860804-26-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-[(3-hydroxyphenoxy)methyl]styrene
• CAS: 860804-26-8
• 化学式: C₁₅H₁₄O₂
• 分子量: 226.275
• InChiKey: ZATCHDMDOJMQSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.61
• 重原子数：
  17.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  29.46
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  4-[(3-hydroxyphenoxy)methyl]styrene 、 (E)-2-(2-溴甲基苯基)-2-甲氧亚胺基乙酸甲酯 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 以58%的产率得到methyl (2E)-2-[2-[[3-[(4-ethenylphenyl)methoxy]phenoxy]methyl]phenyl]-2-methoxyiminoacetate
  参考文献：
  名称：

  Synthesis and biological evaluation of kresoxim-methyl analogues as novel inhibitors of hypoxia-inducible factor (HIF)-1 accumulation in cancer cells

  摘要：

  We designed and synthesized strobilurin analogues as hypoxia-inducible factor (HIF) inhibitors based on the molecular structure of kresoxim-methyl. Biological evaluation in human colorectal cancer HCT116 cells showed that most of the synthesized kresoxim-methyl analogues possessed moderate to potent inhibitory activity against hypoxia-induced HIF-1 transcriptional activation. Three candidates, compounds 11b, 11c, and 11d were identified as potent inhibitors against HIF-1 activation with IC50 values of 0.60-0.94 mu M. Under hypoxic condition, compounds 11b, 11c, and 11d increased the intracellular oxygen contents, thereby attenuating the hypoxia-induced accumulation of HIF-1 alpha protein. (C) 2017 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2017.05.024
• 作为产物：
  描述：

  4-氯甲基苯乙烯 、 间苯二酚 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 18.0h， 以35%的产率得到4-[(3-hydroxyphenoxy)methyl]styrene
  参考文献：
  名称：

  Synthesis and Characterization of Amine-Functionalized Polystyrene Nanoparticles

  摘要：

  Functionalized polymer nanoparticles have been synthesized through an intramolecular cross-linking reaction with polystyrene as the backbone and an amino group as the functional moiety. The intramolecular cross-linking reaction was performed under ultradilute conditions, and the crosslinked polymers were characterized by gel permeation chromatography (GPC), nuclear magnetic resonance (NMR), dynamic light scattering (DLS), and atomic force microscopy (AFM). The availability of the amino moiety in the nanoparticle for further functionalization was confirmed by its reaction with trimethylacetyl chloride.

  DOI：

  10.1021/ma0507286