1-pentylamino-1-deoxy-D-glucitol | 74295-49-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-pentylamino-1-deoxy-D-glucitol
• 英文别名: N-Pentyl-D-glucamin；1-Pentylamino-1-desoxy-D-glucit；N-amyl-d-glucamine；(2R,3R,4R,5S)-6-(pentylamino)hexane-1,2,3,4,5-pentol
• CAS: 74295-49-1
• 化学式: C₁₁H₂₅NO₅
• 分子量: 251.323
• InChiKey: RHCAOXVBDGCLQK-LNFKQOIKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  17
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  113
• 氢给体数：
  6
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1-pentylamino-1-deoxy-D-glucitol 、 二硫化碳 、 sodium hydroxide 、 甲醇 生成 sodium;N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]-N-pentylcarbamodithioate
  参考文献：
  名称：

  JONES, MARK M.;SINGH, PRAMOD K.;JONES, SHIRLEY G.;MUKUNDAN, CHETAN R.;BAN+, CHEM. RES. TOXICOL. , 4,(1991) N, C. 27-34

  摘要：

  DOI：
• 作为产物：
  描述：

  葡萄糖 在 盐酸 、 乙醇 、 镍 作用下， 70.0~83.0 ℃ 、8.83 MPa 条件下， 生成 1-pentylamino-1-deoxy-D-glucitol
  参考文献：
  名称：

  The Reaction of Glucose with Some Amines

  摘要：

  DOI：

  10.1021/ja01231a055

文献信息

• [EN] RESOLUTION OF TETRAHYDROFOLIC ACID DERIVATIVES<br/>[FR] SÉPARATION DE DÉRIVÉS D'ACIDE TÉTRAHYDROFOLIQUE
  申请人：WATSON LAB INC

  公开号：WO2013025203A1

  公开（公告）日：2013-02-21

  A process of preparing (6S)-tetrahydrofolic acid derivatives comprising reacting racemic (6RS)-tetrahydrofolic acid derivatives with N-alkyl-D-glucamine, forming N-alkyl-D-glucamine salts of the (6RS)-tetrahydrofolic acid derivatives, isolation of the N-alkyl-D-glucamine salt of the (6S)-tetrahydrofolic acid derivative, removal of the N-alkyl-D-glucamine cation and purification of the (6S)-tetrahydrofolic acid derivative. The purified (6S)-tetrahydrofolic acid derivative can then be converted into the corresponding alkali metal or alkaline earth metal salts.

  制备（6S）-四氢叶酸衍生物的过程包括将外消旋（6RS）-四氢叶酸衍生物与N-烷基-D-葡糖胺反应，形成（6RS）-四氢叶酸衍生物的N-烷基-D-葡糖胺盐，分离出（6S）-四氢叶酸衍生物的N-烷基-D-葡糖胺盐，去除N-烷基-D-葡糖胺阳离子，并纯化（6S）-四氢叶酸衍生物。然后，纯化的（6S）-四氢叶酸衍生物可以转化为相应的碱金属或碱土金属盐。
• Resolution of 1,4-dihydropyridine derivatives
  申请人：LABORATOIRES SYNTEX S.A.

  公开号：EP0273349A2

  公开（公告）日：1988-07-06

  Optically active compounds of the formula or a salt thereof wherein R, is H or lower alkyl; R2 and R6 are each independently lower alkyl, aryl, or arylalkyl; R3 is CN, N02, C02R5, CONHR5, SO2R5, or P(O)(OR5)2, where R5 is lower alkyl, lower alkoxyalkyl, aryl, or arylalkyl; R4 is aryl, heterocyclyl, or fused-ring heterocyclyl, optionally substituted with one, two, or three halo, N02, CN, lower alkyl, lower alkoxy, lower alkylamino, CF3, OCH2F, or OCF3; are formed from a salt mixture of the compound with a resolving agent in a hot solvent mixture of an organic solvent and water.

  式中的光学活性化合物 或其盐，其中 R 是 H 或低级烷基 R2 和 R6 各自独立地为低级烷基、芳基或芳烷基； R3 是 CN、N02、C02R5、CONHR5、SO2R5 或 P(O)(OR5)2，其中 R5 是低级烷基、低级烷氧基烷基、芳基或芳基烷基； R4 是芳基、杂环基或融合环杂环基，可任选被 1、2 或 3 个卤素、N02、CN、低级烷基、低级烷氧基、低级烷基氨基、CF3、OCH2F 或 O 取代； 在有机溶剂和水的热混合溶剂中，由化合物与溶解剂的盐混合物形成。
• N,N-dialkylpolyhydroxyalkylamines
  申请人：Meier Kristine Ingrid

  公开号：US20060100127A1

  公开（公告）日：2006-05-11

  N,N-Dialkylpolyhydroxyalkylamines may be made by the reductive alkylation of an N-alkylpolyhydroxyalkylamine with an aldehyde or ketone, or with an equivalent compound, in the presence of a transition metal catalyst and hydrogen. The reaction is performed in a reaction solvent that contains at least 30 wt % of an organic solvent. The use of a sufficiently high proportion of an appropriate organic solvent in the reaction mixture reduces the amount of water present in the reaction mixture, and provides rapid reaction rates and high yields of the desired product. The N,N-dialkylpolyhydroxyalkylamines may be used in a wide variety of applications.
• N,N-Dialkylpolyhydroxyalkylamines
  申请人：Meier Ingrid Kristine

  公开号：US20090042749A1

  公开（公告）日：2009-02-12

  N,N-Dialkylpolyhydroxyalkylamines may be made by the reductive alkylation of an N-alkylpolyhydroxyalkylamine with an aldehyde or ketone, or with an equivalent compound, in the presence of a transition metal catalyst and hydrogen. The reaction is performed in a reaction solvent that contains at least 30 wt % of an organic solvent. The use of a sufficiently high proportion of an appropriate organic solvent in the reaction mixture reduces the amount of water present in the reaction mixture, and provides rapid reaction rates and high yields of the desired product. The N,N-dialkylpolyhydroxyalkylamines may be used in a wide variety of applications.