1-(6-(hydroxyamino)-6-oxohexyl)-6-methoxy-4-oxo-N-(3,4,5-trimethoxyphenyl)-1,4-dihydroquinoline-3-carboxamide | 1233375-66-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-(6-(hydroxyamino)-6-oxohexyl)-6-methoxy-4-oxo-N-(3,4,5-trimethoxyphenyl)-1,4-dihydroquinoline-3-carboxamide
• 英文别名: 1-[6-(hydroxyamino)-6-oxohexyl]-6-methoxy-4-oxo-N-(3,4,5-trimethoxyphenyl)quinoline-3-carboxamide
• CAS: 1233375-66-0
• 化学式: C₂₆H₃₁N₃O₈
• 分子量: 513.547
• InChiKey: WWDIAMCCIQTUJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  37
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  136
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• [EN] HETEROCYCLIC COMPOUNDS AS HDAC INHIBITORS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES COMME INHIBITEURS DE HDAC
  申请人：ORCHID RES LAB LTD

  公开号：WO2010073078A2

  公开（公告）日：2010-07-01

  The present invention relates to heterocyclic compounds of the general formula (I) their derivatives, analogs, tautomeric forms, stereoisomers, geometrical isomers, polymorphs, hydrates, solvates, metabolites, prodrugs, pharmaceutically acceptable salts and compositions thereof. Also included is method for treatment of proliferative conditions and cancer, conditions mediated by HDAC, in a mammal comprising administering an effective amount of compound formula (I) as described above.