1-(4-fluorobenzyl)-2-(4-fluorophenyl)-4,5-diphenyl-1H-imidazole | 1567353-69-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(4-fluorobenzyl)-2-(4-fluorophenyl)-4,5-diphenyl-1H-imidazole
• CAS: 1567353-69-8
• 化学式: C₂₈H₂₀F₂N₂
• 分子量: 422.477
• InChiKey: KGXOSRXVBCOLMB-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  联苯甲酰 、 对氟苄胺 在 nickel(II) chloride hexahydrate 作用下， 以 甲苯 为溶剂， 反应 12.0h， 以87%的产率得到1-(4-fluorobenzyl)-2-(4-fluorophenyl)-4,5-diphenyl-1H-imidazole
  参考文献：
  名称：

  Ni(ii)–salt catalyzed activation of primary amine-sp³C_α–H and cyclization with 1,2-diketone to tetrasubstituted imidazoles

  摘要：

  NiCl₂·6H₂O 和 Ni(OAc)₂·4H₂O 被发现是对苄胺和脂肪胺进行C-H活化的高效催化剂，利用1,2-二酮在回流甲苯条件下进行前所未有的多个C-N键形成环化反应，生成高度取代和多环咪唑。

  DOI：

  10.1039/c3cc48437h

文献信息

• An eco-compatible pathway to the synthesis of mono and bis-multisubstituted imidazoles over novel reusable ionic liquids: an efficient and green sonochemical process
  作者：Wael Abdelgayed Ahmed Arafa

  DOI：10.1039/c8ra02755b

  日期：——

  Novel and environmentally benign ionic liquids (ILs) comprised of DABCO were successfully synthesized. These ILs were used as robust catalysts for the sonochemical one pot multi-component synthetic route for the functionalized annulated imidazoles in water with excellent yields. The present protocol scored well in terms of yield economy as compared with the conventional procedures. The merits of the

  成功合成了由 DABCO 组成的新型环保离子液体 (ILs)。这些离子液体被用作声化学一锅多组分合成路线的稳健催化剂，用于在水中以优异的收率实现官能化的环化咪唑。与传统程序相比，本协议在收益经济方面得分很高。当前绿色方法的优点包括简单、适用、广泛的官能团耐受性、干净的反应曲线和无需繁琐的后处理，并且可以提供高至定量的产率。从环境角度来看，这些环保的绿色催化剂可以毫不费力地回收和重复使用至少连续七次，而不会显着降低催化活性。
• DMSO promoted catalyst-free oxidative C–N/C–O couplings towards synthesis of imidazoles and oxazoles
  作者：Debasish Bera、Rajib Sarkar、Tiyasa Dhar、Pinaki Saha、Prasanta Ghosh、Chhanda Mukhopadhyay

  DOI：10.1039/d4ob00383g

  日期：——

  (DMSO)-promoted catalyst-free oxidative C–N coupling and C–O coupling under oxidant-free conditions are outlined. This protocol is operationally simple and leads to various functionalized substituted imidazoles or oxazoles in good yields. To date, a very limited number of oxidation protocols have been established, where DMSO acts solely as a catalyst or an oxidant or both. In this report, DMSO is not only used

  概述了二甲亚砜 (DMSO) 促进的无催化剂氧化 C-N 偶联和无氧化剂条件下的 C-O 偶联。该方案操作简单，并且以良好的产率产生各种官能化的取代咪唑或恶唑。迄今为止，已经建立的氧化方案数量非常有限，其中 DMSO 仅充当催化剂或氧化剂或两者兼而有之。在本报告中，DMSO不仅用作C-N/C-O偶联剂，还用作这些氧化转化所需的氧化剂。因此，我们所证明的 DMSO 促进的无催化剂偶联转化有能力引领氧化偶联领域的新维度。
• One-Pot N-α-C(sp3)–H Bond Functionalisation Cascade for the Synthesis of Polysubstituted Imidazoles
  作者：Vikas D. Kadu、Naga Chandradudu Sankala、Mahesh G. Hublikar、Shahaji I. Bansode、Raghunath B. Bhosale

  DOI：10.1055/s-0043-1763690

  日期：2024.7

  A one-pot eco-friendly oxidative N-α-C(sp3)–H bond functionalisation of arylmethylamines for the synthesis of tetrasubstituted imidazoles is demonstrated. The substrate scope of these amines has been well-explored with different substrates, such as 1,2-diketones, an α-hydroxy ketone and phenylacetophenone. In the presence of FeCl3 catalyst and green oxidant O2, the easily accessible substrates afforded tetrasubstituted imidazoles in up to 94% yield.