N-(3-cyclopropyl-1H-pyrazol-5-yl)-N'-(3-aminophenyl)urea | 326921-03-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3-cyclopropyl-1H-pyrazol-5-yl)-N'-(3-aminophenyl)urea
• 英文别名: 1-(3-aminophenyl)-3-(5-cyclopropyl-1H-pyrazol-3-yl)urea
• CAS: 326921-03-3
• 化学式: C₁₃H₁₅N₅O
• 分子量: 257.295
• InChiKey: LMAUENNWIDTDEI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  95.8
• 氢给体数：
  4
• 氢受体数：
  3

文献信息

• Mice with combined disruption of Gpx1 and Gpx2 genes have growth retardation, hypothermia, and colitis and provide a mouse model for cancer
  申请人：——

  公开号：US20030009776A1

  公开（公告）日：2003-01-09

  Disclosed is a transgenic knockout mouse whose genome has a homozygous disruption in its endogenous Gpx1 and Gpx2 genes, wherein the disruptions result in a decrease in GPX activity in the transgenic mice when compared to non transgenic mice of the same type. Methods for production of the mouse are presented. Also disclosed are cells derived from the transgenic knockout mouse. The invention further provides a mouse model for the disorders of ileitis, colitis,inflammatory bowel disease, ileal cancer and myeloleukemia. The mouse can be used in a method for identifying therapeutic agents for the treatment of an individual diagnosed with one or more of said disorders.

  本发明公开了一种转基因基因敲除小鼠，其基因组中的内源 Gpx1 和 Gpx2 基因被同源干扰，与同类型的非转基因小鼠相比，干扰导致转基因小鼠的 GPX 活性降低。本文还介绍了生产这种小鼠的方法。还公开了从转基因基因敲除小鼠中提取的细胞。本发明进一步提供了回肠炎、结肠炎、炎症性肠病、回肠癌和骨髓白血病等疾病的小鼠模型。该小鼠可用于鉴定治疗被诊断患有一种或多种上述疾病的个体的治疗药物的方法中。
• 3(5)-UREIDO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS
  申请人：Pfizer Italia S.r.l.

  公开号：EP1202734B1

  公开（公告）日：2007-05-02
• EP1202734A4
  申请人：——

  公开号：EP1202734A4

  公开（公告）日：2004-09-01
• JP2003507328A
  申请人：——

  公开号：JP2003507328A

  公开（公告）日：2003-02-25
• US6387900B1
  申请人：——

  公开号：US6387900B1

  公开（公告）日：2002-05-14