chloro-acetic acid 3-acetoxy-6-acetoxymethyl-2-[4-benzyloxy-2-benzyloxymethyl-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-6-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-3-yloxy]-5-chloroacetoxy-tetrahydro-pyran-4-yl ester | 251348-04-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: chloro-acetic acid 3-acetoxy-6-acetoxymethyl-2-[4-benzyloxy-2-benzyloxymethyl-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-6-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-3-yloxy]-5-chloroacetoxy-tetrahydro-pyran-4-yl ester
• CAS: 251348-04-6
• 化学式: C₄₇H₅₅Cl₂NO₁₆Si
• 分子量: 988.942
• InChiKey: HPSJYVROQRFXLN-IESTYGJRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.44
• 重原子数：
  67.0
• 可旋转键数：
  21.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.49
• 拓扑面积：
  197.96
• 氢给体数：
  0.0
• 氢受体数：
  16.0

反应信息

• 作为反应物：
  描述：

  chloro-acetic acid 3-acetoxy-6-acetoxymethyl-2-[4-benzyloxy-2-benzyloxymethyl-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-6-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-3-yloxy]-5-chloroacetoxy-tetrahydro-pyran-4-yl ester 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Expedient synthesis of a series of N-acetyllactosamines

  摘要：

  A series of poly-N-acetyllactosamines representative of those found on complex N-glycans was synthesized for use in the kinetic characterization of recently cloned glycosyltransferases. The syntheses involved the iterative addition of a selectively protected N-acetyllactosaminyl donor to an octyl alpha-D-mannopyranosyl-1,6-beta-mannopyranoside acceptor, followed by deprotection. In addition, non-reducing galactosyl residues were removed with beta-galactosidase to furnish GlcNAc terminated compounds. In this manner tetra- to octasaccharides were efficiently produced. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00485-0
• 作为产物：
  描述：

  2-(三甲基硅烷基)乙基beta-吡喃半乳糖苷 在 吡啶 、 2,3,5-三甲基吡啶 、 1,1-二氯甲醚 、 4 A molecular sieve 、 camphor-10-sulfonic acid 、 silver trifluoromethanesulfonate 、 溶剂黄146 、 zinc(II) chloride 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 26.0h， 生成 chloro-acetic acid 3-acetoxy-6-acetoxymethyl-2-[4-benzyloxy-2-benzyloxymethyl-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-6-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-3-yloxy]-5-chloroacetoxy-tetrahydro-pyran-4-yl ester
  参考文献：
  名称：

  Expedient synthesis of a series of N-acetyllactosamines

  摘要：

  A series of poly-N-acetyllactosamines representative of those found on complex N-glycans was synthesized for use in the kinetic characterization of recently cloned glycosyltransferases. The syntheses involved the iterative addition of a selectively protected N-acetyllactosaminyl donor to an octyl alpha-D-mannopyranosyl-1,6-beta-mannopyranoside acceptor, followed by deprotection. In addition, non-reducing galactosyl residues were removed with beta-galactosidase to furnish GlcNAc terminated compounds. In this manner tetra- to octasaccharides were efficiently produced. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00485-0