9-methoxy-2-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenethoxy)-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-4-one | 1369253-32-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 9-methoxy-2-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenethoxy)-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-4-one
• 英文别名: 9-Methoxy-2-[2-[4-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]ethoxy]-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one
• CAS: 1369253-32-6
• 化学式: C₂₇H₂₂F₃N₃O₄
• 分子量: 509.485
• InChiKey: OWNDETATUFLSJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  37
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  73.2
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• TRICYCLIC COMPOUNDS, PREPARATION METHODS, AND THEIR USES
  申请人：GLAXO GROUP LIMITED

  公开号：US20140378487A1

  公开（公告）日：2014-12-25

  The present invention relates to novel compounds that inhibit Lp-PLA 2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA 2 , for example atherosclerosis, Alzheimer's disease, and/or diabetic macular edema.
• US8871928B2
  申请人：——

  公开号：US8871928B2

  公开（公告）日：2014-10-28