(-)-(S)-N-(alpha-Ethylbenzyl)-3-(carboxymethoxy)-2-phenylquinoline-4-carboxamide | 224961-34-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (-)-(S)-N-(alpha-Ethylbenzyl)-3-(carboxymethoxy)-2-phenylquinoline-4-carboxamide
• 英文别名: 2-[2-phenyl-4-[[(1S)-1-phenylpropyl]carbamoyl]quinolin-3-yl]oxyacetic acid
• CAS: 224961-34-6
• 化学式: C₂₇H₂₄N₂O₄
• 分子量: 440.5
• InChiKey: RJIWGNBRTQFKBW-NRFANRHFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  88.5
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• PROPHYLACTIC OR THERAPEUTIC AGENT AND MEDICINAL COMPOSITION FOR IL-31-MEDIATED DISEASE
  申请人：Kyushu University, National University Corporation

  公开号：EP3881843A1

  公开（公告）日：2021-09-22

  A prophylactic or therapeutic agent for an IL-31 mediated disease, said agent comprising a neurokinin B signal blocker.

  一种 IL-31 介导疾病的预防或治疗药物，所述药物包括神经激肽 B 信号阻断剂。
• ANTI-ANDROGENS AND METHODS FOR TREATING DISEASE
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP1146873A1

  公开（公告）日：2001-10-24
• EP1146873A4
  申请人：——

  公开号：EP1146873A4

  公开（公告）日：2003-03-26
• [EN] ANTI-ANDROGENS AND METHODS FOR TREATING DISEASE<br/>[FR] ANTI-ANDROGENES ET PROCEDES DE TRAITEMENT
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2000043008A1

  公开（公告）日：2000-07-27

  The present invention is the novel use of NK-3 receptor antagonist compounds for the treatment and/or prophylaxis of diseases which are caused by high or inappropriate levels of gonadotropins and/or androgens, particularly testosterone.
• [EN] NOVEL USE<br/>[FR] NOUVELLE UTILISATION
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2002040023A1

  公开（公告）日：2002-05-23

  A method for the treatment or prophylaxis of the common cold, or respiratory viral infection caused by human rhinovirus infection (HRV), other enteroviruses, coronavirus, influenza virus, parainfluenza virus, respiratory syncytial virus, or adenovirus infection in a human in need thereof, which method comprises administering to said human an effective amount of an NK3 antagonist.