2-benzyl-4-(4-fluorophenyl)-4-oxobutanoic acid | 203855-56-5

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物
• 英文名称: 2-benzyl-4-(4-fluorophenyl)-4-oxobutanoic acid
• 英文别名: 4-Fluoro-gamma-oxo-alpha-(phenylmethyl)benzenebutanoic acid
• CAS: 203855-56-5
• 化学式: C₁₇H₁₅FO₃
• 分子量: 286.303
• InChiKey: DZRBTTWGDHUKDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] KYNURENINE 3-HYDROXYLASE INHIBITORS FOR THE TREATMENT OF DIABETES<br/>[FR] INHIBITEURS DE LA KYNURENINE 3-HYDROXYLASE POUR LE TRAITEMENT DU DIABETE
  申请人：MERCK PATENT GMBH

  公开号：WO2004060369A1

  公开（公告）日：2004-07-22

  The present invention relates to the use of at least one compound with inhibitory activity on kynurenine 3-hydroxylase for the preparation of a medicament for the prevention and/or treatment of diabetes.

  本发明涉及使用至少一种对酮烟酸3-羟化酶具有抑制活性的化合物制备用于预防和/或治疗糖尿病的药物。
• Use of 4-oxobutanoic acid derivatives in the treatment of inflammation
  申请人：Moinet Gerard

  公开号：US20050014768A1

  公开（公告）日：2005-01-20

  The present invention relates to the use of a 4-oxobutanoic acid derivative for the preparation of a pharmaceutical composition for treating inflammation.

  本发明涉及使用 4-氧代丁酸衍生物制备治疗炎症的药物组合物。
• Pharmaceutical composition comprising a combination of metformin and a 4-oxobutanoic acid, and the use thereof for treating diabetes
  申请人：Moinet Gerald

  公开号：US20050020609A1

  公开（公告）日：2005-01-27

  The present invention relates to a pharmaceutical composition comprising, as active principles, metformin, optionally in the form of one of it its pharmaceutically acceptable salts, and a 4-oxobutanoic acid, in combination with one or more pharmaceutically acceptable excipients. These compositions are particularly suitable for treating non-insulin-dependent diabetes.

  本发明涉及一种药物组合物，其活性成分包括二甲双胍（可选择以其中一种药学上可接受的盐的形式）和 4-氧代丁酸，以及一种或多种药学上可接受的赋形剂。这些组合物尤其适用于治疗非胰岛素依赖型糖尿病。
• Pharmaceutical composition comprising an alpha-glucosidase inhibitor and a 4-oxobutanoic acid, and the use thereof for treating diabetes
  申请人：Moinet Gerard

  公开号：US20050070553A1

  公开（公告）日：2005-03-31

  The present invention relates to a pharmaceutical composition comprising, as active principles, a 4-oxobutanoic acid and an α-glucosidase inhibitor, in combination with one or more pharmaceutically acceptable excipients. These compositions are particularly suitable for treating diabetes.

  本发明涉及一种药物组合物，其活性成分包括一种 4-氧代丁酸和一种 α-葡萄糖苷酶抑制剂，以及一种或多种药学上可接受的赋形剂。这些组合物尤其适用于治疗糖尿病。
• Pharmaceutical composition comprising a glitazone and a 4-oxobutanoic acid, and the use thereof for treating diabetes
  申请人：Moinet Gerard

  公开号：US20050085489A1

  公开（公告）日：2005-04-21

  The present invention relates to a pharmaceutical composition comprising, as active principles, a 4-oxobutanoic acid and a glitazone, in combination with one or more pharmaceutically acceptable excipients. These compositions are particularly suitable for treating diabetes.

  本发明涉及一种药物组合物，其活性成分包括 4-氧代丁酸和格列酮，以及一种或多种药学上可接受的赋形剂。这些组合物特别适用于治疗糖尿病。