5-benzyl-4-phenyl-1H-1,2,3-triazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-benzyl-4-phenyl-1H-1,2,3-triazole
• 英文别名: 4-benzyl-5-phenyl-2H-triazole
• 化学式: C₁₅H₁₃N₃
• 分子量: 235.288
• InChiKey: BIENZZZEEMIVKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  碘苯 、 5-benzyl-4-phenyl-1H-1,2,3-triazole 在 potassium carbonate 、 L-脯氨酸 、 copper(l) chloride 作用下， 以 二甲基亚砜 为溶剂， 反应 0.5h， 以85%的产率得到4-benzyl-2,5-diphenyl-2H-1,2,3-triazole
  参考文献：
  名称：

  Efficient Synthesis of N-2-Aryl-1,2,3-Triazole Fluorophores via Post-Triazole Arylation

  摘要：

  Efficient post-triazole regloselective N-2 arylation was developed from C-4, C-5 disubstituted-1,2,3-NH-triazoles. Three different approaches had been investigated, including SNAr, Cu(I) catalyzed aryl amidation and Cu(II) mediated boronic acid coupling. The N-2-aryl triazoles were successfully synthesized with excellent yields. The structures were characterized by X-ray crystallography and some N-2-triazole products gave strong fluorescence with various emission controlled by the C-5 groups.

  DOI：

  10.1021/ol802246q
• 作为产物：
  描述：

  (E)-(2-nitroprop-1-ene-1,3-diyl)dibenzene 在 sodium azide 作用下， 以 二甲基亚砜 为溶剂， 反应 0.17h， 以84%的产率得到5-benzyl-4-phenyl-1H-1,2,3-triazole
  参考文献：
  名称：

  的高度多样化合成1,2,3-三唑衍生物通过多米诺[3 + 2]环加成的叠氮化物和脱硝反应序列†

  摘要：

  在本文中，已经描述了在无催化剂的条件下通过多米诺[3 + 2]叠氮化物环加成和脱硝反应的顺序优雅合成1,2,3-三唑衍生物的方法。在没有催化剂存在的情况下，用叠氮化钠处理硝基烯烃对Baylis-Hillman加合物及其环状衍生物的反应，可平稳地获得1,2,3-三唑衍生物。

  DOI：

  10.1039/c5ra14195h

文献信息

• [EN] LUMINESCENT COMPOUNDS AND METHODS OF USING SAME<br/>[FR] COMPOSÉS LUMINESCENTS ET SES PROCÉDÉS D'UTILISATION
  申请人：UNIV KINGSTON

  公开号：WO2014138912A1

  公开（公告）日：2014-09-18

  The invention provides compounds of the general formula (10). The cyclometallating ligand of compound (10) includes an N-donor heterocyclic ligand (2) where at least one X is nitrogen and which is directly bonded to a phenyl group. The phenyl group is orthometallated to the platinum. The donor atoms (Y) of the bidentate stabilizing ligand are N or O. The invention further provides methods of producing photoluminescence and electroluminescence, methods of applying the compounds in thin film, and uses of the compounds of the invention in a light emitting device, a luminescent probe, a sensor, and/or an electroluminescent device.

  该发明提供了通式（10）的化合物。化合物（10）的环金属配体包括N-供体杂环配体（2），其中至少一个X是氮，并且直接与苯基结合。苯基被正金属化到铂。双齿稳定配体的供体原子（Y）为N或O。该发明还提供了产生光致发光和电致发光的方法，将这些化合物应用于薄膜的方法，以及将该发明中的化合物用于发光器件、发光探针、传感器和/或电致发光器件的用途。
• Highly efficient synthesis of vinyl substituted triazoles by Au(I) catalyzed alkyne activation
  作者：Haifeng Duan、Wuming Yan、Sujata Sengupta、Xiaodong Shi

  DOI：10.1016/j.bmcl.2009.03.096

  日期：2009.7

  Au(I) catalyzed 1,2,3-triazole addition to non-activated alkyne was reported. A large group of substituted NH-1,2,3-triazoles were suitable for this transformation along with both internal and terminal alkynes. The N-1 and N-2 vinyl substituted 1,2,3-triazoles were prepared in up to 98% yield with as low as 0.2% catalyst loading, thereby providing a new protocol for the synthesis of potentially biological-active vinyl-triazole building blocks. (C) 2009 Elsevier Ltd. All rights reserved.
• [EN] FLUORESCENT CYCLOMETALATED Ir (III) COMPLEXES AND FORMULATIONS/ COMPOSITIONS COMPRISING THE SAME<br/>[FR] COMPLEXES IR (III) CYCLOMÉTALLÉS FLUORESCENTS ET FORMULATIONS/COMPOSITIONS LES COMPRENANT
  申请人：GUPTA PARNA

  公开号：WO2017046813A1

  公开（公告）日：2017-03-23

  Fluorescent cyclometalated Ir(III) complexes and/or salts thereof are provided including formulations/ compositions comprising the same together with its process of preparation that is found to be highly efficient in causing photo- induced death of cancer cells on exposure to laser illumination and also specifically localize and exhibit fluorescence in the endoplasmic reticulum, when employed in effective amounts.