2-[3-(2-phenylethylamino)-2-oxo-2H-quinolin-1-yl]acetic acid | 308131-70-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-[3-(2-phenylethylamino)-2-oxo-2H-quinolin-1-yl]acetic acid
• 英文别名: 2-[2-Oxo-3-(2-phenylethylamino)quinolin-1-yl]acetic acid
• CAS: 308131-70-6
• 化学式: C₁₉H₁₈N₂O₃
• 分子量: 322.364
• InChiKey: VDGOYZODFBRFPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  69.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
  申请人：South S. Michael

  公开号：US20050165062A1

  公开（公告）日：2005-07-28

  The invention relates to substituted polycyclic aryl and heteroaryl pyridone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.

  该发明涉及替代的多环芳基和杂环芳基吡啶酮化合物，可用作凝血级联中丝氨酸蛋白酶的抑制剂，以及用于治疗和预防各种血栓性疾病，包括冠状动脉和脑血管疾病的抗凝治疗的化合物、组合物和方法。
• SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRIDONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE
  申请人：Pharmacia Corporation

  公开号：EP1178964A1

  公开（公告）日：2002-02-13
• US6870056B1
  申请人：——

  公开号：US6870056B1

  公开（公告）日：2005-03-22
• US6867217B1
  申请人：——

  公开号：US6867217B1

  公开（公告）日：2005-03-15
• [EN] SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRIDONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE<br/>[FR] PYRIDONES ARYLE ET HETEROARYLE POLYCYCLIQUES SUBSTITUEES UTILISEES POUR L'INHIBITION SELECTIVE DE LA CASCADE DE COAGULATION
  申请人：MONSANTO CO

  公开号：WO2000069826A1

  公开（公告）日：2000-11-23

  The invention relates to substituted polycyclic aryl and heteroaryl pyridone compounds having Formula (I) or a pharmaceutically acceptable salt thereof, wherein: a.o., Γ is selected from the group consisting of NH and NOH; useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.