acyl-b-D-glucuronide | 77668-22-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: acyl-b-D-glucuronide
• 英文别名: 1-O-Acetyl-beta-D-glucopyranuronic acid；(2S,3S,4S,5R,6S)-6-acetyloxy-3,4,5-trihydroxyoxane-2-carboxylic acid
• CAS: 77668-22-5
• 化学式: C₈H₁₂O₈
• 分子量: 236.178
• InChiKey: KKQGLALOFAYFGV-UQGZVRACSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  134
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• [EN] CANNABINOIDS AND USES THEREOF<br/>[FR] CANNABINOÏDES ET UTILISATIONS ASSOCIÉES
  申请人：CORBUS PHARMACEUTICALS INC

  公开号：WO2021113669A1

  公开（公告）日：2021-06-10

  The invention relates to cannabinoid compounds, pharmaceutical compositions including one or more cannabinoid compounds, and the use of pharmaceutical compositions including one or more cannabinoid compounds for the treatment of a disease or condition (e.g., a fibrotic disease or an inflammatory disease) in a subject in need thereof.

  该发明涉及大麻素化合物、包括一个或多个大麻素化合物的药物组合物，以及利用包括一个或多个大麻素化合物的药物组合物治疗患有疾病或症状（例如，纤维化疾病或炎症性疾病）的患者的用途。
• [EN] TRICYCLIC HETEROCYCLES USEFUL AS TEAD BINDERS<br/>[FR] HÉTÉROCYCLES TRICYCLIQUES UTILES EN TANT QUE LIANTS TEAD
  申请人：MERCK PATENT GMBH

  公开号：WO2021224291A1

  公开（公告）日：2021-11-11

  The present invention relates to tricyclic heterocycles. These heterocyclic compounds are useful as TEAD binders and/or inhibitors of YAP-TEAD and TAZ-TEAD protein-protein interaction or binding and for the prevention and/or treatment of several medical conditions including hyperproliferative disorders and diseases, in particular cancer.

  本发明涉及三环杂环化合物。这些杂环化合物可用作TEAD结合物，和/或YAP-TEAD和TAZ-TEAD蛋白质间的相互作用或结合的抑制剂，用于预防和/或治疗包括过度增殖性疾病和疾病在内的多种医疗条件，特别是癌症。
• ANTI-HYPERCHOLESTEROLEMIC COMPOUNDS
  申请人：Merck & Co., Inc.

  公开号：EP1699760A2

  公开（公告）日：2006-09-13
• [EN] WATER-SOLUBLE DERIVATIVES OF PACLITAXEL, METHOD FOR PRODUCING SAME AND USES THEREOF<br/>[FR] DERIVES SOLUBLES A L'EAU DE PACLITAXEL, PROCEDES DE PRODUCTION ET UTILISATION DE CES DERIVES
  申请人：BCM DEV INC

  公开号：WO2000001682A1

  公开（公告）日：2000-01-13

  The invention relates to new paclitaxel derivatives showing an increased solubility in water. More particularly, the invention relates to glutarylpaclitaxel, glutarylpaclitaxel 6-aminohexanol glucuronide and to different amino acid derivatives of the glutarylpaclitaxel, all of which possess the cytotoxicity activity of the parent compound, paclitaxel. The present invention also relates to the use of such derivative for treating cancer. Also disclosed are fluorescent derivatives of paclitaxel for determining a concentration of paclitaxel in a medium or for detecting apoptotic cancer cells.
• [EN] ANTI-HYPERCHOLESTEROLEMIC COMPOUNDS<br/>[FR] COMPOSES ANTI-HYPERCHOLESTEROLEMIE
  申请人：MERCK & CO INC

  公开号：WO2005062824A2

  公开（公告）日：2005-07-14

  This invention provides cholesterol absorption inhibitors of formula (I), and the pharmaceutically acceptable salts and esters thereof. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating and preventin atherosclerosis and atherosclerotic disease events.