| 1350539-43-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1350539-43-3
• 化学式: C₄₀H₅₆F₆N₂O₃₃
• 分子量: 1206.87
• InChiKey: XOHNTLSXQLCAFE-LKZIZYEYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -11.77
• 重原子数：
  81.0
• 可旋转键数：
  19.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  554.85
• 氢给体数：
  19.0
• 氢受体数：
  30.0

反应信息

• 作为反应物：
  描述：

  在 水 、 三乙胺 作用下， 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  Chemoenzymatic Design of Heparan Sulfate Oligosaccharides*

  摘要：

  Heparan sulfate is a sulfated glycan that exhibits essential physiological functions. Interrogation of the specificity of heparan sulfate-mediated activities demands a library of structurally defined oligosaccharides. Chemical synthesis of large heparan sulfate oligosaccharides remains challenging. We report the synthesis of oligosaccharides with different sulfation patterns and sizes from a disaccharide building block using glycosyl-transferases, heparan sulfate C-5-epimerase, and sulfotransferases. This method offers a generic approach to prepare heparan sulfate oligosaccharides possessing predictable structures.

  DOI：

  10.1074/jbc.m110.159152
• 作为产物：
  描述：

  6-[[[5-(2,4-二氧代嘧啶-1-基)-3,4-二羟基四氢呋喃-2-基]甲氧基-羟基磷酰]氧基-羟基磷酰]氧基-3,4,5-三羟基四氢吡喃-2-羧酸 在 Escherichia coli K₅ N-acetyl-D-glucosaminyl transferase 、 heparosan synthase-2 、 magnesium chloride 作用下， 生成
  参考文献：
  名称：

  Chemoenzymatic Design of Heparan Sulfate Oligosaccharides*

  摘要：

  Heparan sulfate is a sulfated glycan that exhibits essential physiological functions. Interrogation of the specificity of heparan sulfate-mediated activities demands a library of structurally defined oligosaccharides. Chemical synthesis of large heparan sulfate oligosaccharides remains challenging. We report the synthesis of oligosaccharides with different sulfation patterns and sizes from a disaccharide building block using glycosyl-transferases, heparan sulfate C-5-epimerase, and sulfotransferases. This method offers a generic approach to prepare heparan sulfate oligosaccharides possessing predictable structures.

  DOI：

  10.1074/jbc.m110.159152