1-{[(4-Phenylamino)phenylamino]carbonyl}-4-{4-{[2-thienyl(imino)methyl]amino}phenyl}-piperazine Hydrochloride | 262446-87-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-{[(4-Phenylamino)phenylamino]carbonyl}-4-{4-{[2-thienyl(imino)methyl]amino}phenyl}-piperazine Hydrochloride
• 英文别名: 4-[4-[[amino(thiophen-2-yl)methylidene]amino]phenyl]-N-(4-anilinophenyl)piperazine-1-carboxamide;hydrochloride
• CAS: 262446-87-7
• 化学式: C₂₈H₂₈N₆OS*ClH
• 分子量: 533.097
• InChiKey: KDRGIOMWFUNECA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.71
• 重原子数：
  37
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  114
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• New derivatives of N-(iminomethy)amines, their preparation, their use as medicaments and the pharmaceutical compositions containing them
  申请人：SOCIETE DE CONSEILS DE RECHERCHES D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.)

  公开号：US20040097494A1

  公开（公告）日：2004-05-20

  N-(imino)amines and their preparation and their use as NO synthase inhibitors and selective or non-selective traps for a reactive oxygen species.

  N-(亚胺基)胺及其制备方法，以及作为NO合酶抑制剂和对反应性氧化物的选择性或非选择性陷阱的用途。
• Derivatives of N-(iminomethyl)amines, their preparation, their use as medicaments and the pharmaceutical compositions containing them
  申请人：Bigg Dennis

  公开号：US20050197329A1

  公开（公告）日：2005-09-08

  N-(imino)amines and their preparation and their use as NO synthase inhibitors and selective or non-selective traps for a reactive oxygen species.

  N-(亚硝基)胺及其制备方法和用作NO合酶抑制剂和选择性或非选择性捕捉反应性氧化物种的用途。
• New derivatives of N-(iminomethyl)amines, their preparation, their use as medicaments and the pharmaceutical compositions containing them
  申请人：Bigg Dennis

  公开号：US20050027009A1

  公开（公告）日：2005-02-03

  N-(imino)amines and their preparation and their use as NO synthase inhibitors and selective or non-selective traps for a reactive oxygen species.

  N-(亚硝基)胺及其制备方法和用途，作为NO合酶抑制剂和选择性或非选择性的反应性氧化物陷阱。
• US6482822B1
  申请人：——

  公开号：US6482822B1

  公开（公告）日：2002-11-19
• US6620840B1
  申请人：——

  公开号：US6620840B1

  公开（公告）日：2003-09-16