tert-butyl N-[(2R)-1-(2-fluorophenyl)-4-[[4-[3-(2-methyl-1,3-thiazol-5-yl)phenyl]thian-4-yl]amino]-4-oxobutan-2-yl]carbamate | 939803-18-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tert-butyl N-[(2R)-1-(2-fluorophenyl)-4-[[4-[3-(2-methyl-1,3-thiazol-5-yl)phenyl]thian-4-yl]amino]-4-oxobutan-2-yl]carbamate
• CAS: 939803-18-6
• 化学式: C₃₀H₃₆FN₃O₃S₂
• 分子量: 569.765
• InChiKey: HFOPKEVCGPYCTA-XMMPIXPASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  39
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  134
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  tert-butyl N-[(2R)-1-(2-fluorophenyl)-4-[[4-[3-(2-methyl-1,3-thiazol-5-yl)phenyl]thian-4-yl]amino]-4-oxobutan-2-yl]carbamate 在 盐酸 、 间氯过氧苯甲酸 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成 (3R)-3-amino-4-(2-fluorophenyl)-N-[4-[3-(2-methyl-1,3-thiazol-5-yl)phenyl]-1,1-dioxothian-4-yl]butanamide
  参考文献：
  名称：

  Novel series of 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides as potent and selective dipeptidyl peptidase IV inhibitors

  摘要：

  A series of novel 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides were investigated as dipeptidyl peptidase IV (DPP-4) inhibitors. Introduction of a 4-phenylthiazol-2-yl group showed highly potent DPP-4 inhibitory activity. Among various derivatives, (3R)-3-amino-N-(4-(4-phenylthiazol-2-yl)-tetrahydro-2H-thiopyran-4-yl)-4-(2,4,5-trifluorophenyl)butanamide 1,1-dioxide (30) reduced blood glucose excursion in an oral glucose tolerance test by oral administration. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.09.099
• 作为产物：
  描述：

  4-(3-Iodophenyl)thian-4-amine 在 N-甲基咪唑 、 四(三苯基膦)钯 、 对甲苯磺酰氯 作用下， 以 乙腈 为溶剂， 生成 tert-butyl N-[(2R)-1-(2-fluorophenyl)-4-[[4-[3-(2-methyl-1,3-thiazol-5-yl)phenyl]thian-4-yl]amino]-4-oxobutan-2-yl]carbamate
  参考文献：
  名称：

  Novel series of 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides as potent and selective dipeptidyl peptidase IV inhibitors

  摘要：

  A series of novel 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides were investigated as dipeptidyl peptidase IV (DPP-4) inhibitors. Introduction of a 4-phenylthiazol-2-yl group showed highly potent DPP-4 inhibitory activity. Among various derivatives, (3R)-3-amino-N-(4-(4-phenylthiazol-2-yl)-tetrahydro-2H-thiopyran-4-yl)-4-(2,4,5-trifluorophenyl)butanamide 1,1-dioxide (30) reduced blood glucose excursion in an oral glucose tolerance test by oral administration. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.09.099

文献信息

• Novel series of 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides as potent and selective dipeptidyl peptidase IV inhibitors
  作者：Aiko Nitta、Hideaki Fujii、Satoshi Sakami、Mikiya Satoh、Junko Nakaki、Shiho Satoh、Hiroki Kumagai、Hideki Kawai

  DOI：10.1016/j.bmcl.2012.09.099

  日期：2012.12

  A series of novel 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides were investigated as dipeptidyl peptidase IV (DPP-4) inhibitors. Introduction of a 4-phenylthiazol-2-yl group showed highly potent DPP-4 inhibitory activity. Among various derivatives, (3R)-3-amino-N-(4-(4-phenylthiazol-2-yl)-tetrahydro-2H-thiopyran-4-yl)-4-(2,4,5-trifluorophenyl)butanamide 1,1-dioxide (30) reduced blood glucose excursion in an oral glucose tolerance test by oral administration. (C) 2012 Elsevier Ltd. All rights reserved.