| 1333477-23-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1333477-23-8
• 化学式: C₁₁₂H₁₇₀N₂O₂₂P₂
• 分子量: 1958.53
• InChiKey: YRBJUEBRZICJOD-HILHVFKDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  26.3
• 重原子数：
  138.0
• 可旋转键数：
  81.0
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  296.16
• 氢给体数：
  4.0
• 氢受体数：
  22.0

反应信息

• 作为产物：
  描述：

  1,2 di-[6-O-benzyl-2-deoxy-4-O-(di-O-benzylphosphono)-3-O-(9-fluorenylmethoxycarbonyl)-2-((R)-3-tetradecanoyloxytetradecanamido)-β-D-glucopyranosyloxy]ethane 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 四氢呋喃 为溶剂， 生成 、 、
  参考文献：
  名称：

  Synthesis of a dimeric monosaccharide lipid A mimic and its synergistic effect on the immunostimulatory activity of lipopolysaccharide

  摘要：

  Bacterial endotoxin lipopolysaccharide (LPS) is a potent immune stimulant, with the recognition of LPS and its active principal lipid A mediated by the Toll-like receptor 4 (TLR4)/MD-2 receptor complex. Due to the broad downstream implications of TLR4-mediated signalling, TLR4 ligands show great potential for immunotherapeutic manipulations. In this paper a dimeric monosaccharide lipid A mimic (3) has been designed as a potential TLR4 ligand. The chemical synthesis and the preliminary biological studies are described. Compound 3 shows a significant synergistic effect on LPS-induced ICAM-1 expression in human monocytic THP-1 cells. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2011.05.018