methyl (4,8-anhydro-2,3-di-O-benzyl-6,7-dideoxy-8S-C-phenyl-α-D-manno-octopyranosyl)-(1→4)-2,3,6-tri-O-benzyl-α-D-glucopyranoside | 1421832-90-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl (4,8-anhydro-2,3-di-O-benzyl-6,7-dideoxy-8S-C-phenyl-α-D-manno-octopyranosyl)-(1→4)-2,3,6-tri-O-benzyl-α-D-glucopyranoside
• CAS: 1421832-90-7
• 化学式: C₅₆H₆₀O₁₀
• 分子量: 893.086
• InChiKey: WSUUZKGLLFCYEK-UXXLXUGJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.95
• 重原子数：
  66.0
• 可旋转键数：
  20.0
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  92.3
• 氢给体数：
  0.0
• 氢受体数：
  10.0

反应信息

• 作为产物：
  描述：

  甲基2,3,6-三-O-苄基-ALPHA-D-吡喃葡萄糖苷 、 三氟甲磺酸酐 、 phenylthio 4,8-anhydro-2,3-di-O-benzyl-6,7-dideoxy-8S-phenyl-α-D-manno-octopyranoside 在 1-(苯基亚硫酰基)哌啶 、 2,4,6-三叔丁基嘧啶 作用下， 以 二氯甲烷 为溶剂， 反应 1.5h， 以33.333%的产率得到
  参考文献：
  名称：

  Influence of O6 in Mannosylations Using Benzylidene Protected Donors: Stereoelectronic or Conformational Effects?

  摘要：

  The stereoselective synthesis of beta-mannosides and the underlying reaction mechanism have been thoroughly studied, and especially the benzylidene-protected mannosides have gained a lot of attention since the corresponding mannosyl triflates often give excellent selectivity. The hypothesis for the enhanced stereoselectivity has been that the benzylidene locks the molecule in a less reactive conformation with the O6 trans to the ring oxygen (O5), which would stabilize the formed alpha-triflate and subsequent give beta-selectivity. In this work, the hypothesis is challenged by using the carbon analogue (C7) of the benzylidene-protected mannosyl donor, which is investigated in terms of diastereoselectivity and reactivity and by low-temperature NMR In terms of diastereoselectivity, the C-7-analogue behaves similarly to the benzylidene-protected donor, but its low-temperature NMR reveals the formation of several reactive intermediate. One of the intermediates was found to be the beta-oxosulfonium ion. The reactivity of the donor was found to be in between that of the "torsional" disarmed and an armed donor.

  DOI：

  10.1021/jo302455d