2-(2,4-dimethoxybenzoyl)quinazolin-4(3H)-one | 1417283-53-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(2,4-dimethoxybenzoyl)quinazolin-4(3H)-one
• CAS: 1417283-53-4
• 化学式: C₁₇H₁₄N₂O₄
• 分子量: 310.309
• InChiKey: TVYSMPQIWQKMEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.17
• 重原子数：
  23.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  81.28
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  2-氨基苯甲酰胺 、 2,4-二甲氧基苯乙酮 在 碘 作用下， 以 二甲基亚砜 为溶剂， 以60%的产率得到2-(2,4-dimethoxybenzoyl)quinazolin-4(3H)-one
  参考文献：
  名称：

  Direct One-Pot Synthesis of Luotonin F and Analogues via Rational Logical Design

  摘要：

  An efficient one-pot synthetic protocol has been proposed for the synthesis of luntonin F from easily available starting materials. Through a rational logical design, multifundamental reactions (iodination, Kornblum oxidation, and annulation) were assembled in one-pot. The developed approach can efficiently synthesize luntonin F and a diversity of analogues.

  DOI：

  10.1021/ol303331g

文献信息

• Green Synthesis of 2-Benzoyl-4-quinazolinones
  作者：Zhijie Li、Yamei Pu、Dezhi Qiu、Xiaoping Zhang、Qingle Zeng

  DOI：10.14233/ajchem.2015.18677

  日期：——

  A catalyst-free synthesis of 2-benzoyl-4-quinazolinones is described here. Anthranilamides and a-haloacetophenones were used as the starting reagents. The effects of molar ratio of reactants, catalyst, solvent, base, temperature and time on the reaction were investigated and then the optimal reaction conditions were achieved. All of the substrates examined under the optimized conditions gave high yields. Compared to traditional synthesis method of 2-benzoyl-4-quinazolinones, this method has several advantages, such as no catalyst, cost saving and environmentally benign process.

  本文描述了一种无催化剂的2-苯甲酰基-4-喹唑啉酮的合成方法。采用邻氨基苯甲酰胺和α-卤代乙酰苯作为起始试剂。研究了反应物摩尔比、催化剂、溶剂、碱、温度和时间对反应的影响，并获得了最佳反应条件。在优化的条件下，所有检测的底物均能获得高产率。与传统的2-苯甲酰基-4-喹唑啉酮合成方法相比，该方法具有无催化剂、节约成本和环境友好的优点。