[(S)-2-((2R,3R,4S,5S,6S)-3-Hydroxy-4,5-dimethoxy-6-methyl-tetrahydro-pyran-2-yloxy)-1-methyl-ethyl]-carbamic acid benzyl ester | 142739-22-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [(S)-2-((2R,3R,4S,5S,6S)-3-Hydroxy-4,5-dimethoxy-6-methyl-tetrahydro-pyran-2-yloxy)-1-methyl-ethyl]-carbamic acid benzyl ester
• CAS: 142739-22-8
• 化学式: C₁₉H₂₉NO₇
• 分子量: 383.442
• InChiKey: QUVVHWWYIQRUQJ-PNIOIJOISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.45
• 重原子数：
  27.0
• 可旋转键数：
  8.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  95.48
• 氢给体数：
  2.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  [(S)-2-((2R,3R,4S,5S,6S)-3-Hydroxy-4,5-dimethoxy-6-methyl-tetrahydro-pyran-2-yloxy)-1-methyl-ethyl]-carbamic acid benzyl ester 在 4 A molecular sieve 、 三氟化硼乙醚 、 sodium methylate 作用下， 以 甲醇 、 氯仿 为溶剂， 反应 3.5h， 生成
  参考文献：
  名称：

  Synthesis of the glycopeptide - O-(3,4-di-O-methyl-2-O-[3,4-di-O-methyl-α-L-rhamnopyranosyl]-α-L-rhamnopyranosyl)-L-alanilol: An unusual part structure in the glycopeptidolipid of

  摘要：

  The stereoselective synthesis of the title compound, an unusual variant in the structure of glycopeptidolipid of M. fortuitum, by involving glycosyltrichloroacetimidate methodology has been described.

  DOI：

  10.1016/s0040-4020(01)88483-0
• 作为产物：
  描述：

  O-(2-O-acetyl-3,4-di-O-methyl-α-L-rhamnopyranosyl)-N-carbobenzyloxy-L-alanilol 在 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 3.0h， 以0.19 g的产率得到[(S)-2-((2R,3R,4S,5S,6S)-3-Hydroxy-4,5-dimethoxy-6-methyl-tetrahydro-pyran-2-yloxy)-1-methyl-ethyl]-carbamic acid benzyl ester
  参考文献：
  名称：

  Synthesis of the glycopeptide - O-(3,4-di-O-methyl-2-O-[3,4-di-O-methyl-α-L-rhamnopyranosyl]-α-L-rhamnopyranosyl)-L-alanilol: An unusual part structure in the glycopeptidolipid of

  摘要：

  The stereoselective synthesis of the title compound, an unusual variant in the structure of glycopeptidolipid of M. fortuitum, by involving glycosyltrichloroacetimidate methodology has been described.

  DOI：

  10.1016/s0040-4020(01)88483-0