methyl 3-O-(2-acetamido-2-deoxy-α-D-galactopyranosyl)-α-D-galactopyranoside | 130234-67-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl 3-O-(2-acetamido-2-deoxy-α-D-galactopyranosyl)-α-D-galactopyranoside
• 英文别名: Methyl 3-O-(2-acetamido-2-deoxy-a-D-galactopyranosyl)-a-D-galactopyranoside；N-[(2R,3R,4R,5R,6R)-2-[(2R,3S,4S,5R,6S)-3,5-dihydroxy-2-(hydroxymethyl)-6-methoxyoxan-4-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide
• CAS: 130234-67-2
• 化学式: C₁₅H₂₇NO₁₁
• 分子量: 397.379
• InChiKey: USJPBCYUZSGJII-HRFDEUMXSA-N

物化性质

• 沸点：
  772.3±60.0 °C(Predicted)
• 密度：
  1.54±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.6
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  187
• 氢给体数：
  7
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  2-硝基苯基-2-乙酰氨基-2-脱氧-α-D-吡喃半乳糖苷 、 Α-D-乳酸吡喃糖苷甲酯 以5 mg的产率得到methyl 3-O-(2-acetamido-2-deoxy-α-D-galactopyranosyl)-α-D-galactopyranoside
  参考文献：
  名称：

  Enzymic synthesis of HexNAc-containing disaccharide glycosides

  摘要：

  The following disaccharide glycosides were obtained from the appropriate donor and acceptor glycosides by employing glycosidases from the mollusc Chamelea gallina as catalysts: alpha-D-Galp-OMe (N-acetyl-alpha-D- galactosaminidase), beta-D-GalpNAc-(1----3)-beta-D-Galp-OMe, beta-D-GlcpNAc-(1----3)-beta-D-Galp-OMe, and beta-D-GlcpNAc-(1----6)-alpha-D-Manp-OMe (N-acetyl-beta-D-hexosaminidase). The regioselectivity of the N-acetyl-beta-D-hexosaminidase-catalysed reactions depended on the anomeric configuration of the acceptor. Thus, alpha-D-Galp-OMe gave beta-D-GlcpNAc- (1----6)-alpha-D-Galp-OMe almost exclusively, whereas beta-D-Galp-OMe gave beta-D-GlcpNAc-(1----3)-beta-D-Galp-OMe and beta-D-GlcpNAc-(1----6)-beta-D-Galp-OMe in almost equal amounts. The isolation of the products by chromatography was straightforward.

  DOI：

  10.1016/0008-6215(90)84022-m

文献信息

• PROCESS FOR PRODUCING AN OLIGOSACCHARIDE COMPOUND BY USING GLYCOSIDASES FROM A MOLLUSC
  申请人：PROCUR AKTIEBOLAG

  公开号：EP0487607B1

  公开（公告）日：1995-05-17
• US5372937A
  申请人：——

  公开号：US5372937A

  公开（公告）日：1994-12-13
• US5599694A
  申请人：——

  公开号：US5599694A

  公开（公告）日：1997-02-04