1-[2,8-bis(trifluoromethyl)quinolin-4-yl]-2-(dibutylamino)ethanol | 69760-32-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-[2,8-bis(trifluoromethyl)quinolin-4-yl]-2-(dibutylamino)ethanol
• 英文别名: α-Di-n-butylaminomethyl-2,8-bis-(trifluormethyl)-4-chinolinmethanol；WR176990
• CAS: 69760-32-3
• 化学式: C₂₁H₂₆F₆N₂O
• 分子量: 436.441
• InChiKey: AHDMCPDJZBURTG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  36.4
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• Quninoline Methanol Compounds for the Treatment and Prevention of Parasitic Infections
  申请人：Dow Geoffrey

  公开号：US20110092488A1

  公开（公告）日：2011-04-21

  Malaria is responsible for 1-2 million deaths and 300-500 million clinical cases annually and is an ever present problem for the military, tourists and business travelers. Mefloquine is known and used for malaria prophylaxis. However it is associated with neurological effects. The present invention is directed to providing new and novel quinoline analogs that are less neurotoxic than mefloquine without compromising efficacy. The present invention is also directed to the prevention and treatment of other microbial, parasitic, protozoan, bacterial and fungal diseases.
• [EN] COMPOSITIONS FOR THE TREATMENT OF CANCER AND USES THEREOF<br/>[FR] COMPOSITIONS DESTINÉES AU TRAITEMENT DU CANCER, ET LEURS UTILISATIONS
  申请人：UNIV FLORIDA

  公开号：WO2016209688A1

  公开（公告）日：2016-12-29

  The invention pertains to compositions comprising inhibitors of PI3K, AKT and/or mTOR, one or more 4-quinolinemethanols and a pharmaceutically acceptable excipient. These compositions can contain subtherapeutic amounts of each active ingredient (PI3K, AKT, mTOR, one or more 4-quinolinemethanols and various combinations thereof). The invention also provides a method of treating various forms of cancer, such as breast cancer, prostate cancer, multiple myeloma, hepatocyte carcinoma, brain cancer, lung cancer, non- small cell lung carcinoma, colorectal cancer, melanoma and/or pancreatic cancer.