N-((2R,3R)-3-hydroxy-2-methylnonanoyl)-N-Me-L-Leu-L-Ile-L-Ser(Bn)-OAllyl | 694527-82-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-((2R,3R)-3-hydroxy-2-methylnonanoyl)-N-Me-L-Leu-L-Ile-L-Ser(Bn)-OAllyl
• CAS: 694527-82-7
• 化学式: C₃₆H₅₉N₃O₇
• 分子量: 645.88
• InChiKey: ODGUXFWAAGUYPU-RJFDUGEUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.79
• 重原子数：
  46.0
• 可旋转键数：
  23.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  134.27
• 氢给体数：
  3.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  N-((2R,3R)-3-hydroxy-2-methylnonanoyl)-N-Me-L-Leu-L-Ile-L-Ser(Bn)-OAllyl 在 palladium dihydroxide 、 四(三苯基膦)钯 吗啉 、 4-二甲氨基吡啶 、 camphor-10-sulfonic acid 、 四丁基氟化铵 、 氢气 、 溶剂黄146 、 N,N-二异丙基乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 、 N,N'-二异丙基碳二亚胺 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 反应 78.0h， 生成 cyclo[Gly-ObAla(2R-Me,3R-hexyl)-N(Me)Leu-Ile-Ser-Thr]
  参考文献：
  名称：

  Structure–activity relationships of globomycin analogues as antibiotics

  摘要：

  Globomycin (1a), a signal peptidase II inhibitor, and its derivatives show potent antibacterial activity against Gram-negative bacteria. The synthesis and antimicrobial activity of novel globomycin analogues are reported. The hydroxyl group in the L-Ser residue was essential for the antimicrobial activity and the length of the alkyl side chain greatly influenced the activity. In addition, derivatives that had a modified cyclic core exhibited weak activity. One of the analogues showed a wider antimicrobial spectrum, effective against not only Gram-negative but also Gram-positive bacteria. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2003.10.055
• 作为产物：
  描述：

  Boc-L-Ile-L-Ser(Bn)-OAll 在 盐酸 、 氰基磷酸二乙酯 、 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 乙酸乙酯 为溶剂， 生成 N-((2R,3R)-3-hydroxy-2-methylnonanoyl)-N-Me-L-Leu-L-Ile-L-Ser(Bn)-OAllyl
  参考文献：
  名称：

  Structure–activity relationships of globomycin analogues as antibiotics

  摘要：

  Globomycin (1a), a signal peptidase II inhibitor, and its derivatives show potent antibacterial activity against Gram-negative bacteria. The synthesis and antimicrobial activity of novel globomycin analogues are reported. The hydroxyl group in the L-Ser residue was essential for the antimicrobial activity and the length of the alkyl side chain greatly influenced the activity. In addition, derivatives that had a modified cyclic core exhibited weak activity. One of the analogues showed a wider antimicrobial spectrum, effective against not only Gram-negative but also Gram-positive bacteria. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2003.10.055

文献信息

• Synthesis and antimicrobial activity of novel globomycin analogues
  作者：Toshihiro Kiho、Mizuka Nakayama、Kayo Yasuda、Shunichi Miyakoshi、Masatoshi Inukai、Hiroshi Kogen

  DOI：10.1016/s0960-894x(03)00432-3

  日期：2003.7

  Globomycin, a signal peptidase II inhibitor, and its derivatives show potent antibacterial activity against Gram-negative bacteria. The synthesis and antimicrobial activity of novel globomycin analogues are reported. One of the analogues showed a more potent activity against Gram-negative bacteria than globomycin and also exhibited antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). (C) 2003 Elsevier Science Ltd. All rights reserved.