N-[3-(2-azatricyclo[3.3.1.1(3,7)]dec-2-yl)propyl]-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxamide hydrochloride | 1274918-60-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-[3-(2-azatricyclo[3.3.1.1(3,7)]dec-2-yl)propyl]-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxamide hydrochloride
• 英文别名: N-[3-(2-azatricyclo[3.3.1.13,7]decan-2-yl)propyl]-4-hydroxy-1-methyl-2-oxoquinoline-3-carboxamide;hydrochloride
• CAS: 1274918-60-3
• 化学式: C₂₃H₂₉N₃O₃*ClH
• 分子量: 431.963
• InChiKey: PYCHDRWPHXUCNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.05
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  72.9
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• L -DIHYDRO-2-OXOQUINOLINE COMPOUNDS AS 5-HT4 RECEPTOR LIGANDS
  申请人：Suven Life Sciences Limited

  公开号：EP2507225B1

  公开（公告）日：2016-06-01
• 1,2-DIHYDRO-2-OXOQUINOLINE COMPOUNDS AS 5-HT4 RECEPTOR LIGANDS
  申请人：Nirogi Ramakrishna

  公开号：US20120277216A1

  公开（公告）日：2012-11-01

  The present invention relates to novel 1,2-dihydro-2-oxoquinoline compounds of the formula (I), and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them. The compounds of the present invention are useful in the treatment/prevention of various disorders that are mediated by 5-HT4 receptor activity.
• US8598204B2
  申请人：——

  公开号：US8598204B2

  公开（公告）日：2013-12-03