2(R)-Methylglutaric acid 5-tert-butyl ester | 140408-50-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2(R)-Methylglutaric acid 5-tert-butyl ester
• 英文别名: (2R)-2-methyl-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoic acid
• CAS: 140408-50-0
• 化学式: C₁₀H₁₈O₄
• 分子量: 202.251
• InChiKey: VNKZWBDCRSFNCP-SSDOTTSWSA-N

物化性质

• 沸点：
  304.3±25.0 °C(Predicted)
• 密度：
  1.052±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2(R)-Methylglutaric acid 5-tert-butyl ester 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 3.0h， 生成 Dimethyl <4-<(tert-butoxycarbonyl)-2(R)-methylbutyryl>amino><(phenylthio)methyl>malonate
  参考文献：
  名称：

  Dimethyl amino[(phenylthio)methyl]malonate: a useful C-3 unit in a mild, direct synthesis of oxazole-4-carboxylates

  摘要：

  N-Acyl derivatives of the title compound undergo oxidative cyclization upon treatment with N-chlorosuccinimide in DMF to form dimethyl 4,5-dihydro(phenylthio)oxazole-4,4-dicarboxylates 4 which then are decarbomethoxylated with concomitant loss of thiophenoxide to form 2-substituted-4-carbomethoxy-5-unsubstituted oxazoles 1. The mildness and generality of this method has been demonstrated by the synthesis of a variety of examples, including a fragment used for a synthesis of calyculin A.

  DOI：

  10.1021/jo00073a040
• 作为产物：
  描述：

  丙烯酸叔丁酯 在 titanium(IV) isopropylate 、 lithium hydroxide monohydrate 、 水 、 双氧水 、 四氯化钛 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 18.5h， 生成 2(R)-Methylglutaric acid 5-tert-butyl ester
  参考文献：
  名称：

  WO2024079623A1

  摘要：

  公开号：

文献信息

• BIOPROBES AND METHODS OF USE THEREOF
  申请人：The Governing Council of the University of Toronto

  公开号：US20160298177A1

  公开（公告）日：2016-10-13

  Disclosed are biomolecule based bioprobes that exhibit improved water solubility and mono layer-forming properties with substantially little or no aggregation that can appreciably interfere with binding of the bioprobes to a target nucleotide. The bioprobes may be used in conjunction with a suitable reporter system to detect very small quantities of biological markers. The bio-probes comprise a nucleobase sequence capable of hybridizing to a target nucleotide; and at least one charged functional group attached to said nucleobase sequence. Also disclosed are biosensors, and sensing devices that comprise the bin-probe. Further disclosed are suitable electrochemical reporter systems for use with the bioprobes. Methods of use of these devices and probes, including for the detection of target biomarkers, including biomarkers for cancer cells or pathogens, are also included.
• (ANTI-HER2 ANTIBODY)-DRUG CONJUGATE
  申请人：DAIICHI SANKYO COMPANY, LIMITED

  公开号：US20170035906A1

  公开（公告）日：2017-02-09

  As an antitumor drug which is excellent in terms of antitumor effect and safety and has an excellent therapeutic effect, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-HER2 antibody via a linker having a structure represented by the formula: L 1 -L 2 -L P -NH—(CH 2 )n 1 -L a -L b -L c or -L 1 -L 2 -L P - wherein the anti-HER2 antibody is connected to the terminal L 1 , and the antitumor compound is connected to the terminal L c or L P with the nitrogen atom of the amino group at position 1 as the connecting position.