6-(2(R)-(1(R)-fluoro-2,2,2-trifluoroethyl)-4(S)-fluoro-1-pyrrolidinyl)-4-trifluoromethyl-2(1H)-quinolinone | 847235-90-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-(2(R)-(1(R)-fluoro-2,2,2-trifluoroethyl)-4(S)-fluoro-1-pyrrolidinyl)-4-trifluoromethyl-2(1H)-quinolinone
• 英文别名: 6-[(2R,4S)-4-fluoro-2-[(1R)-1,2,2,2-tetrafluoroethyl]pyrrolidin-1-yl]-4-(trifluoromethyl)-1H-quinolin-2-one
• CAS: 847235-90-9
• 化学式: C₁₆H₁₂F₈N₂O
• 分子量: 400.271
• InChiKey: BZOPTHCTDIGCMS-AAAAQAOESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• 6-Cycloamino-2-quinolinone derivatives as androgen receptor modulator compounds
  申请人：Zhi Lin

  公开号：US20070066650A1

  公开（公告）日：2007-03-22

  The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR. Also provided are methods of making such compounds and pharmaceutical compositions.
• PHARMACEUTICAL COMPOSITION FOR INHIBITING AMYLOID-beta PROTEIN ACCUMULATION
  申请人：Motonaga Kozo

  公开号：US20100204216A1

  公开（公告）日：2010-08-12

  The present invention provides: a pharmaceutical composition for inhibiting amyloid-β protein accumulation comprising a compound represented by the formulas including (I) or a pharmaceutically acceptable salt thereof; a method for inhibiting amyloid-β protein accumulation, comprising a step of administering an effective amount of the compound represented by the formulas including (I) or a pharmaceutically acceptable salt thereof to a mammal which may be diagnosed with an amyloid-β protein-related disease; and so on.
• US7816372B2
  申请人：——

  公开号：US7816372B2

  公开（公告）日：2010-10-19