3,4-Dihydroxy-1-phenyl-carbostyril | 21641-07-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3,4-Dihydroxy-1-phenyl-carbostyril
• 英文别名: 3,4-Dihydroxy-1-phenyl-2-chinolon；3,4-dihydroxy-1-phenyl-1H-quinolin-2-one；1-Phenyl-3,4-Dihydroxy-2(1H)-Quinolinone；3,4-Dihydroxy-1-phenylquinolin-2-one
• CAS: 21641-07-6
• 化学式: C₁₅H₁₁NO₃
• 分子量: 253.257
• InChiKey: VFGIYAMKWUELGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  60.8
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-phenyl-3-oximino-quinolin-2,4(1H)-dione 生成 3,4-Dihydroxy-1-phenyl-carbostyril
  参考文献：
  名称：

  Certain N-substituted 3-oximino-2,4-dioxoquinolin-2,4-(1H)diones useful

  摘要：

  抗DNA病毒剂的化合物，例如疱疹病毒组，已被披露。这些化合物选自以下组合：##STR1##及其药用可接受的盐和溶剂。披露了含有代表公式1.00的化合物的药物组合物。还披露了使用代表公式1.00的化合物治疗病毒感染的方法。公式1.00的化合物也可用作化合物的中间体：##STR2##。公式1.0的化合物可用作抗同样病毒的抗病毒剂，这些病毒与公式1.00的化合物具有相同的作用。

  公开号：

  US05190956A1

文献信息

• Antiviral quinolinone compounds
  申请人：Schering Corporation

  公开号：US05179107A1

  公开（公告）日：1993-01-12

  Compounds useful as antiviral agents against DNA containing viruses, such as herpes group viruses, are disclosed. The compounds are selected from the group consisting of: ##STR1## and their pharmaceutically acceptable salts and solvates. Pharmaceutical compositions containing compounds represented by Formula 1.0 are disclosed. Also disclosed are methods of treating a viral infection using compounds represented by Formula 1.0. A process for making compounds of Formula 1.0 from the appropriate 3-oximino-quinolin-2,4(1H)-dione (Formula 2.5) is also disclosed. The process comprises reductively hydrolyzing an appropriate 3-oximino-quinolin-2,4(1H)-dione (Formula 2.5) in a mixture with a hydrogenation catalyst and an acidic solvent mixture.

  揭示了作为抗DNA含病毒（如疱疹病毒组）的抗病毒剂的有用化合物。这些化合物选自以下组合物：##STR1##及其药学上可接受的盐和溶剂。揭示了含有代表Formula 1.0的化合物的药物组合物。还揭示了使用代表Formula 1.0的化合物治疗病毒感染的方法。还揭示了一种从适当的3-氧基亚喹啉-2,4(1H)-二酮（Formula 2.5）制备Formula 1.0化合物的过程。该过程包括在含有氢化催化剂和酸性溶剂混合物的混合物中还原水解适当的3-氧基亚喹啉-2,4(1H)-二酮（Formula 2.5）。
• Quinolinone derivative and antiallergic agent with said quinolinone derivative as the active ingredient
  申请人：DAINIPPON INK AND CHEMICALS, INC.

  公开号：EP0785190A2

  公开（公告）日：1997-07-23

  The present invention offers 7-aminoquinolinone derivatives, physiologically acceptable salts thereof, anti-allergic agents having as an active ingredient a 7-aminoquinolinone derivative or physiologically acceptable salt thereof, and 7-nitroquinolinone derivatives, wherein the 7-aminoquinolinone derivative is expressed by the following general formula (I):    wherein R1 is a hydrogen atom or an alkyl group; R2 and R3 are mutually different groups, each of which is selected from among hydrogen atoms, acyl groups, alkyl groups or alkenyl groups; and R4 and R5 are mutually different or identical groups, each of which is selected from among hydrogen atoms, acyl groups, alkyl groups, alkenyl groups or aralkyl groups; and physiologically acceptable salts thereof.

  本发明提供了7-氨基喹啉酮衍生物、其生理学上可接受的盐、以7-氨基喹啉酮衍生物或其生理学上可接受的盐为活性成分的抗过敏剂，以及7-硝基喹啉酮衍生物，其中7-氨基喹啉酮衍生物由以下通式(I)表示： 其中 R1 是氢原子或烷基； R2 和 R3 是互不相同的基团，每个基团选自氢原子、酰基、烷基或烯基；以及 R4 和 R5 是相互不同或相同的基团，各自选自氢原子、酰基、烷基、烯基或芳烷基； 及其生理上可接受的盐类。
• Quinolinone derivative, method for preparing the same, and anti-allergic agent
  申请人：DAINIPPON INK AND CHEMICALS, INC.

  公开号：EP0927718A1

  公开（公告）日：1999-07-07

  The present invention relates to a simple method for preparing a quinolinone derivative, which is effective as a medicine, e.g., as an agent for treating allergic diseases and the like; novel amide derivatives effective as an intermediate in the method; novel quinolinone derivatives obtained according to the method; and an anti-allergic agent contaiirng a quinolinone derivative and/or physiological salt of the same as the active ingredients. The quinolinone derivative is expressed by the following general formula (II); and the method is characterized in that an amide derivative, expressed by the following general formula (I), is reacted with a basic agent, followed by intramolecular ring formation:    General Formula (I)    [wherein, R1 represents a hydrogen atom, an alkyl group, an alkyl group containing a hydroxyl group, an alkenyl group, or an aryl group; R2 represents an alkyl group, an alkenyl group, an aryl group, or an aralkyl group; R3 represents a reactive carboxyl group; and R4 to R7 represent, respectively and independently, a hydrogen atom, a hydroxyl group, an alkyl group, an alkoxy group, an alkenyl group, an alkenyloxy group, an aryl group, an aryloxy group, an aralkyloxy group, a R8R9N group (wherein, R8 and R9 represent, respectively and independently, a hydrogen atom, an alkyl group, an aikenyl group, an aralkyl group, or an acyl group), a nitro group, or a R10OOC group (wherein, R10 represents a hydrogen atom, an alkyl group, an alkenyl group, an aryl group, or an aralkyl group)].    General Formula (II)    [wherein, R1, R2 and R4 to R7 represent, respectively, the same constituents as described in general formula (I)].

  本发明涉及一种制备喹啉酮衍生物的简便方法，该衍生物可有效地用作药物，如治疗过敏性疾病等的药物；在该方法中作为中间体有效的新型酰胺衍生物；根据该方法获得的新型喹啉酮衍生物；以及含有喹啉酮衍生物和/或其生理盐作为有效成分的抗过敏药物。喹啉酮衍生物由以下通式（II）表示；该方法的特征在于，由以下通式（I）表示的酰胺衍生物与碱性剂反应，然后进行分子内成环： 通式 (I) [其中，R1 代表氢原子、烷基、含羟基的烷基、烯基或芳基；R2 代表烷基、烯基、芳基或芳烷基；R3 代表活性羧基；以及 R4 至 R7 分别独立地代表氢原子、羟基、烷基、烷氧基、烯基、烯氧基、芳基、芳氧基、芳烷氧基、R8R9N 基团（其中，R8 和 R9 分别独立地代表氢原子、羟基、烷基、烷氧基、烯基、烯氧基、芳氧基、芳烷氧基、芳烷氧基）、分别独立地代表氢原子、烷基、烯基、芳基或酰基）、硝基或 R10OOC 基团（其中，R10 代表氢原子、烷基、烯基、芳基或芳基）]。 通式 (II) [其中，R1、R2 和 R4 至 R7 分别代表与通式 (I) 所述相同的成分]。
• US5179107A
  申请人：——

  公开号：US5179107A

  公开（公告）日：1993-01-12
• US5190956A
  申请人：——

  公开号：US5190956A

  公开（公告）日：1993-03-02