4-cyclohexyl-2-(1-methoxy-ethyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-quinoline-3-carboxylic acid ethyl ester | 1186525-13-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-cyclohexyl-2-(1-methoxy-ethyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-quinoline-3-carboxylic acid ethyl ester
• 英文别名: Ethyl 4-cyclohexyl-2-(1-methoxyethyl)-7,7-dimethyl-5-oxo-6,8-dihydroquinoline-3-carboxylate
• CAS: 1186525-13-2
• 化学式: C₂₃H₃₃NO₄
• 分子量: 387.519
• InChiKey: JORPUIOQKAJQHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  65.5
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] TRICYCLIC PYRIDINE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PREPARATION<br/>[FR] DÉRIVÉS DE PYRIDINES TRICYCLIQUES, MÉDICAMENTS CONTENANT CES COMPOSÉS, LEUR UTILISATION ET LEUR PROCÉDÉ DE PRÉPARATION
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2009109549A1

  公开（公告）日：2009-09-11

  Compounds of formula (I) wherein the groups R1 to R8 have the meanings indicated in the description, the tautomers.the stereoisomers.the mixtures thereof and the salts thereof have valuable pharmacological properties.which make them useful for the treatment of cardiovascular and related disorders.

  式（I）中的化合物，其中基团R1至R8具有描述中所指的含义，其互变异构体、立体异构体、混合物及其盐具有有价值的药理特性，使它们在治疗心血管及相关疾病方面具有用途。
• Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation
  申请人：Wagner Holger

  公开号：US20110021550A1

  公开（公告）日：2011-01-27

  Compounds of formula (I) wherein the groups R1 to R8 have the meanings indicated in the description, the tautomers, the stereoisomers, the mixtures thereof and the salts thereof have valuable pharmacological properties, which make them useful for the treatment of cardiovascular and related disorders.

  式（I）的化合物，其中R1至R8的基团具有说明书中所示的含义，其互变异构体、立体异构体、混合物和盐具有有价值的药理特性，使它们可用于治疗心血管和相关疾病。
• TRICYCLIC PYRIDINE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PREPARATION
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2268644B1

  公开（公告）日：2011-08-17
• US8703793B2
  申请人：——

  公开号：US8703793B2

  公开（公告）日：2014-04-22