ethyl 2-[(8S)-3-iodo-5,6,7,8-tetrahydroquinolin-8-yl]acetate | 904929-20-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: ethyl 2-[(8S)-3-iodo-5,6,7,8-tetrahydroquinolin-8-yl]acetate
• CAS: 904929-20-0
• 化学式: C₁₃H₁₆INO₂
• 分子量: 345.18
• InChiKey: ZHXNDNDGXLKLMR-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Antidiabetic Bicyclic Compounds
  申请人：Ge Min

  公开号：US20080090865A1

  公开（公告）日：2008-04-17

  Bicyclic compounds containing a fused pyridine ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.