2,4-dibenzoyl-3-oxo-glutaric acid | 861570-37-8

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物
• 英文名称: 2,4-dibenzoyl-3-oxo-glutaric acid
• 英文别名: α.γ.ε-Trioxo-α.ε-diphenyl-pentan-β.δ-dicarbonsaeure；β-Oxo-α.γ-dibenzoyl-propan-α.γ-dicarbonsaeure；α.α'-Dibenzoyl-aceton-α.α'-dicarbonsaeure；2,4-Dibenzoyl-3-oxo-glutarsaeure
• CAS: 861570-37-8
• 化学式: C₁₉H₁₄O₇
• 分子量: 354.316
• InChiKey: GZDHKNLSKGLDKG-UHFFFAOYSA-N

物化性质

• 熔点：
  162 °C(Solv: benzene (71-43-2))
• 沸点：
  623.9±55.0 °C(Predicted)
• 密度：
  1.417±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.72
• 重原子数：
  26.0
• 可旋转键数：
  8.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  125.81
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  乙醇 、 2,4-dibenzoyl-3-oxo-glutaric acid 在 盐酸 作用下， 生成 2,4-dibenzoyl-3-oxo-glutaric acid diethyl ester
  参考文献：
  名称：

  Neonatal Hearing Loss in the Indigent

  摘要：

  AbstractObjective To compare the risk factor profile for neonatal hearing loss (HL), and the follow‐up rate of those identified with HL in an indigent population with those in an insured population.Study Design Retrospective review.Methods We studied 4526 neonates from the high‐risk nursery or neonatal intensive care unit from two adjacent hospitals in Houston, Texas. Ben Taub General Hospital (BTGH) is a county public hospital that serves mainly the indigent. Texas Children's Hospital (TCH) is a private tertiary care center that serves patients with private insurance and Medicaid.Results Overall, 133 infants failed the screening test. Follow‐up diagnostic testing identified 48 patients with definite HL. Although nearly twice as many patients at BTGH failed screening compared with TCH (88 vs. 45), four times as many patients at BTGH did not return for diagnostic testing (43 vs. 10). When a hearing aid was needed, there was a delay in getting one at BTGH (P <.05). There was a higher prevalence of dysmorphic facial features and central nervous system disease and a lower prevalence of long‐term ventilatory support at BTGH (P <.05). There were no differences between BTGH and TCH in the prevalence of low birth weight, neonatal asphyxia, syndromic stigmata, neonatal infection, family history of HL, or neonatal transfusion (P >.1).Conclusions Significant differences in the risk factor profile for neonatal HL exist between the indigent and the general population. A worrisome problem exists with the timely intervention in hearing‐impaired indigent neonates.

  DOI：

  10.1097/00005537-200202000-00015
• 作为产物：
  描述：

  1,3-丙酮二羧酸 、 苯甲酸酐 生成 2,4-dibenzoyl-3-oxo-glutaric acid
  参考文献：
  名称：

  Neonatal Hearing Loss in the Indigent

  摘要：

  AbstractObjective To compare the risk factor profile for neonatal hearing loss (HL), and the follow‐up rate of those identified with HL in an indigent population with those in an insured population.Study Design Retrospective review.Methods We studied 4526 neonates from the high‐risk nursery or neonatal intensive care unit from two adjacent hospitals in Houston, Texas. Ben Taub General Hospital (BTGH) is a county public hospital that serves mainly the indigent. Texas Children's Hospital (TCH) is a private tertiary care center that serves patients with private insurance and Medicaid.Results Overall, 133 infants failed the screening test. Follow‐up diagnostic testing identified 48 patients with definite HL. Although nearly twice as many patients at BTGH failed screening compared with TCH (88 vs. 45), four times as many patients at BTGH did not return for diagnostic testing (43 vs. 10). When a hearing aid was needed, there was a delay in getting one at BTGH (P <.05). There was a higher prevalence of dysmorphic facial features and central nervous system disease and a lower prevalence of long‐term ventilatory support at BTGH (P <.05). There were no differences between BTGH and TCH in the prevalence of low birth weight, neonatal asphyxia, syndromic stigmata, neonatal infection, family history of HL, or neonatal transfusion (P >.1).Conclusions Significant differences in the risk factor profile for neonatal HL exist between the indigent and the general population. A worrisome problem exists with the timely intervention in hearing‐impaired indigent neonates.

  DOI：

  10.1097/00005537-200202000-00015