β-Ribofuranosylacetic Acid | 77984-45-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: β-Ribofuranosylacetic Acid
• 英文别名: 2-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]acetic acid
• CAS: 77984-45-3
• 化学式: C₇H₁₂O₆
• 分子量: 192.169
• InChiKey: ZMMGVEQQQWRSJQ-VYFZPWGTSA-N

物化性质

• 沸点：
  504.5±40.0 °C(Predicted)
• 密度：
  1.543±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  107
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2,3-O-Isopropylidene-β-ribofuranosylacetic Acid 以 丙酮 为溶剂， 反应 24.0h， 以97%的产率得到β-Ribofuranosylacetic Acid
  参考文献：
  名称：

  Synthesis of a triazole homo-C-nucleoside

  摘要：

  DOI：

  10.1021/jo00330a004

文献信息

• [EN] DEAZAPURINE NUCLEOSIDE ANALOGS AND THEIR USE AS THERAPEUTIC AGENTS<br/>[FR] ANALOGUES DE NUCLEOSIDES DESAZAPURINE ET UTILISATION DE CEUX-CI EN TANT QU'AGENTS THERAPEUTIQUES
  申请人：RIBAPHARM INC

  公开号：WO2003062257A1

  公开（公告）日：2003-07-31

  Methods, compositions, and uses for various nucleoside analog libraries and library compounds are provided. Particularly preferred nucleosides include 6-C-purine nucleosides, 7,8-substituted purine nucleosides, pyrazolopyrimidine nucleoside analogs, various pyrimidine nucleosides, and triazine nucleosides, while preferred uses especially include use of such compounds as pharmacological, and particularly antiviral agents.
• [EN] NUCLEOSIDE LIBRARIES AND COMPOUNDS BY MCC COMBINATORIAL STRATEGIES ON SOLID SUPPORT<br/>[FR] BIBLIOTHEQUES NUCLEOSIDIQUES ET COMPOSES OBTENUS AU MOYEN DE STRATEGIES COMBINATOIRES MCC REALISEES SUR SUPPORT SOLIDE
  申请人：RIBAPHARM INC

  公开号：WO2003052053A2

  公开（公告）日：2003-06-26

  Nucleoside analog libraries and compounds contained herein are prepared in a solid phase combinatorial library approach. In some preferred aspects, diverse heterocyclic bases and/or diverse nucleoside substituents are prepared in a multiple component condensation (MCC), while in other preferred aspects library diversity is generated using solid phase-coupled nucleosides in a series of at least two modification reactions. Particularly preferred compounds include nucleoside analogs generated using contemplated libraries, which may be useful in treatment of various conditions, particularly viral infections and neoplastic diseases.