3,4,2',3',4',6'-Hexa-O-acetyl-α-gentiobiose 1,2-(ethylorthoacetate) | 141541-06-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3,4,2',3',4',6'-Hexa-O-acetyl-α-gentiobiose 1,2-(ethylorthoacetate)
• CAS: 141541-06-2
• 化学式: C₂₈H₄₀O₁₈
• 分子量: 664.615
• InChiKey: DSABJMYETRBWMO-IKRAGANKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  46.0
• 可旋转键数：
  12.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  213.18
• 氢给体数：
  0.0
• 氢受体数：
  18.0

反应信息

• 作为产物：
  描述：

  乙醇 、 Hepta-O-acetyl-gentiobiosyl bromide 在 2,6-二甲基吡啶 、 四丁基氟化铵 作用下， 反应 18.0h， 以67%的产率得到3,4,2',3',4',6'-Hexa-O-acetyl-α-gentiobiose 1,2-(ethylorthoacetate)
  参考文献：
  名称：

  Synthesis and antitumour activity of derivatives of curdlan and lichenan branched at C-6

  摘要：

  Derivatives of curdlan and lichenan, linear (1 --> 3)-beta-D- and (1 --> 3/1 --> 4)-beta-D-glucans, respectively, have been synthesised having alpha-L-arabinofuranosyl, alpha-L-rhamnosyl, beta-D-glucosyl, and beta-gentiobiosyl side chains attached at positions 6. These water-soluble derivatives, obtained by condensation of the 2,4- and 2,4-/2,3-di-O-phenylcarbamoyl derivatives of curdlan and lichenan, respectively, with appropriate ortho esters followed by saponification, were characterised by methylation analysis, g.p.c., and interaction with Congo Red. The curdlan derivatives and the lichenan derivative with few glucosyl branches were active against the Sarcoma 180.

  DOI：

  10.1016/0008-6215(92)84071-y