4-[4,5-二(苯基)-1H-咪唑-2-基]苯甲酰肼 | 151589-38-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 4-[4,5-二(苯基)-1H-咪唑-2-基]苯甲酰肼
• 英文名称: 2-(4-hydrazinocarbonyl-phenyl) 4,5-diphenylimidazole
• 英文别名: 2-(4-hydrazinocarbonylphenyl)-1,5-diphenylimidazole；2-(4-hydrazinocarbonylphenyl)-4,5-diphenylimidazole；4-(4,5-Diphenyl-1H-imidazol-2-yl)benzohydrazide
• CAS: 151589-38-7
• 化学式: C₂₂H₁₈N₄O
• 分子量: 354.411
• InChiKey: AVWFCOAUPSRLKL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83.8
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  DL-肉碱盐酸盐 、 4-[4,5-二(苯基)-1H-咪唑-2-基]苯甲酰肼 在 吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二甲基甲酰胺 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以48%的产率得到[4-[2-[4-(4,5-diphenyl-1H-imidazol-2-yl)benzoyl]hydrazinyl]-2-hydroxy-4-oxobutyl]-trimethylazanium;chloride
  参考文献：
  名称：

  用2-（4-肼基羰基苯基）-4,5-二苯基咪唑通过荧光标记的高效液相色谱法测定人血浆中的肉碱和酰基肉碱。

  摘要：

  肉碱和酰基肉碱是参与脂肪酸氧化和代谢的重要物质。提出了一种HPLC方法，用于这些化合物的定量分析。该方法基于对肉毒碱以及标记有2-（4-肼基羰基苯基）-4,5-二苯基咪唑（HCPI）的短链和中链酰基肉碱的荧光衍生物的检测。使用1-乙基-3-（3-二甲基氨基丙基）碳二亚胺作为缩合试剂，在室温下用HCPI标记肉碱和酰基肉碱。使用乙腈/ Tris-HCl缓冲液的梯度洗脱系统在十八烷基甲硅烷基硅胶（ODS）色谱柱上分离使用阳离子交换盒制备的分析物，并使用合成内标进行测定。荧光检测在475 nm处进行，并在340 nm处进行激发。肉碱，乙酰基，丙酰基，己酰基和辛酰基肉碱的检出限范围为每毫升人血浆0.24至1.97 nmol，信噪比为3。测定的日内和日间精密度血浆样品中的肉碱和酰基肉碱的相对标准偏差（RSD）低于10.3％。该方法可成功测定人血浆中游离肉碱，酰基肉碱和总肉碱的浓度。

  DOI：

  10.1248/cpb.44.1525

文献信息

• INDICATOR FOR ASSESSING BODY ODOR, PROCESS FOR PRODUCING THE SAME, BODY ODOR ASSESSMENT METHOD, METHOD OF ASSESSING EFFICACIOUSNESS OF DEODORANT AND KIT FOR CONVENIENTLY ASSESING BODY ODOR
  申请人：Kao Corporation

  公开号：EP1553411A1

  公开（公告）日：2005-07-13

  An indicator material for assessing body odor of the present invention comprises at least one member selected from the group consisting of a substance (A) which is a β-hydroxycarboxylic acid compound represented by the formula (1), a substance (B) which is a derivative of the compound represented by the formula (1), a substance (C) which is an alcohol compound having a mercapto group at the 3-position represented by the formula (2),and a substance (D) which is a derivative of the compound represented by the formula (2). The present invention also provides a method of producing the compound represented by the formula (2) by incubating perspiration originated from a human in an environment with an oxygen concentration of 10 v/v% or less. The present invention also provides a kit for assessing body odor of a human, wherein the kit for assessing body odor of a human includes a coloration reagent which reacts with β-hydroxycarboxylic acid originated from perspiration of a human. wherein R1 is an alkyl having 1 to 4 carbons; R2 is a hydrogen atom or an alkyl having 1 to 4 carbons, and the total number of carbons in the formula (1) is 10 or less; wherein R3 is a hydrogen atom or methyl group; R4 is an alkyl group having 1 to 3 carbons; and R5 is a hydrogen atom or a methyl group, the total number of carbons is 8 or less.

  本发明的一种用于评估体味的指示剂材料包括至少一种选自以下组成的成员：一种物质（A），它是β-羟基羧酸化合物，由式（1）表示；一种物质（B），它是由式（1）表示的化合物的衍生物；一种物质（C），它是由式（2）表示的在3-位上具有巯基的醇化合物；以及一种物质（D），它是由式（2）表示的化合物的衍生物。本发明还提供了一种通过在氧气浓度为 10 v/v% 或更低的环境中培养人的汗液来生产式（2）所代表的化合物的方法。本发明还提供了一种用于评估人的体味的试剂盒，其中用于评估人的体味的试剂盒包括一种与源自人的汗液的β-羟基羧酸反应的着色试剂。 其中 R1 是具有 1 至 4 个碳原子的烷基；R2 是氢原子或具有 1 至 4 个碳原子的烷基，且式（1）中的碳原子总数为 10 或更少； 其中 R3 是氢原子或甲基；R4 是具有 1 至 3 个碳原子的烷基；R5 是氢原子或甲基，碳原子总数为 8 或更少。
• Indicator for assessing body odor, process for producing the same, body odor assessment method, method of assessing efficaciousness of deodorant and kit for conveniently assessing body odor
  申请人：Hasegawa Yoshihiro

  公开号：US20060160240A1

  公开（公告）日：2006-07-20

  An indicator material for assessing body odor of the present invention comprises at least one member selected from the group consisting of a substance (A) which is a β-hydroxycarboxylic acid compound represented by the formula (1), a substance (B) which is a derivative of the compound represented by the formula (1), a substance (C) which is an alcohol compound having a mercapto group at the 3-position represented by the formula (2),and a substance (D) which is a derivative of the compound represented by the formula (2). The present invention also provides a method of producing the compound represented by the formula (2) by incubating perspiration originated from a human in an environment with an oxygen concentration of 10 v/v % or less. The present invention also provides a kit for assessing body odor of a human, wherein the kit for assessing body odor of a human includes a coloration reagent which reacts with β-hydroxycarboxylic acid originated from perspiration of a human.

  本发明的一种用于评估体味的指示剂材料包括至少一种选自以下组成的成员：一种物质（A），它是β-羟基羧酸化合物，由式（1）表示；一种物质（B），它是由式（1）表示的化合物的衍生物；一种物质（C），它是由式（2）表示的在3-位上具有巯基的醇化合物；以及一种物质（D），它是由式（2）表示的化合物的衍生物。本发明还提供了一种通过在氧气浓度为 10 v/v % 或更低的环境中培养人的汗液来生产式（2）所代表的化合物的方法。本发明还提供了一种用于评估人的体味的试剂盒，其中用于评估人的体味的试剂盒包括一种着色试剂，该试剂与源自人的汗液的β-羟基羧酸反应。
• COMPOSITIONS AND METHODS FOR DETECTION OF SOILS ON FABRICS
  申请人：The Sun Products Corporation

  公开号：EP2601048A2

  公开（公告）日：2013-06-12
• INDICATOR FOR ASSESSING BODY ODOR, PROCESS FOR PRODUCING THE SAME, BODY ODOR ASSESSMENT METHOD, METHOD OF ASSESSING EFFICACIOUSNESS OF DEODORANT AND KIT FOR CONVENIENTLY ASSESSING BODY ODOR
  申请人：Yabuki Masayuki

  公开号：US20100184122A1

  公开（公告）日：2010-07-22

  A method of assessing body odor using as an index an indicator material comprising an alcohol compound having a mercapto group at the 3-position represented by the following formula (2) and/or a substance that is a derivative of an alcohol compound having a mercapto group at the 3-position, wherein an atom(s) or an atom group(s) is introduced to a mercapto group and/or a hydroxyl group of an alcohol compound having a mercapto group at the 3-position represented by the formula (2):
• Compositions and Methods for Detection of Soils on Fabrics
  申请人：GRANJA Mark

  公开号：US20120196375A1

  公开（公告）日：2012-08-02

  The present invention is in the field of household cleaning, for example laundry products and methods. The invention is directed to the use of indicator materials, such as fluorescent indicator materials, for detecting or visualizing organic laundry soils, particularly those that tend to be invisible to the naked eye, such as sebum, perspiration, biological soils, odor-causing soils/stains and tannins. In addition, the present invention is directed to methods of using indicator materials, such as fluorescent indicator materials, to detect such soils on fabrics, and to determine and demonstrate the cleaning efficacy of a laundry product.